Cardiovascular Disease Risk is Associated with Middle Cerebral Artery Blood Flow Velocity in Older Adults

Overview

Journal Cardiopulm Phys Ther J

Specialty Cardiology & Vascular Diseases

Date 2020 Oct 26

PMID 33100924

Citations 11

Authors

Sophy J Perdomo

Jaimie Ward

Yumei Liu

Eric D Vidoni

Jason F Sisante

Kiersten Kirkendoll

Jeffrey M Burns

Sandra A Billinger

Affiliations

Soon will be listed here.

Abstract

Purpose: The aim of this study was to evaluate the of cardiovascular disease (CVD) on middle cerebral blood flow velocity (MCAv) at rest and during exercise. A secondary aim was to explore the relationship between MCAv and 1) the presence of white matter lesions and 2) cognitive function.

Methods: We recruited individuals who were cognitively normal older adults. CVD risk was assessed by the Pooled Cohort atherosclerotic cardiovascular disease (ASCVD) risk score. Transcranial Doppler ultrasound measured middle cerebral artery at rest and during a bout of moderate intensity exercise. We quantified white matter lesions from MRI and cognitive function outcomes included executive function, language, processing speed, and attention.

Results: Seventy-two participants 70.1 ± 4.7 years of age completed the study protocol. ASCVD risk score was significantly associated with resting and exercise MCAv (p<0.01) but not associated with white matter lesions (p>0.468). We observed a significant association between resting and exercise MCAv and language processing (p=0.010) but not other cognitive domains.

Conclusion: In cognitively normal older adults, higher ASCVD risk score was associated with blunted resting and exercise MCAv and with lower language processing performance. These results highlight the need for CVD risk management to maintain optimal brain health.

Citing Articles

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Effects of Physical Exercise on Cerebral Blood Velocity in Older Adults: A Systematic Review and Meta-Analysis.

Prudente T, Oliva H, Oliveira Oliva I, Mezaiko E, Monteiro-Junior R Behav Sci (Basel). 2023; 13(10).

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Fat Consumption Attenuates Cortical Oxygenation during Mental Stress in Young Healthy Adults.

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Lower middle cerebral artery blood velocity during low-volume high-intensity interval exercise in chronic stroke.

Whitaker A, Waghmare S, Montgomery R, Aaron S, Eickmeyer S, Vidoni E J Cereb Blood Flow Metab. 2023; 44(5):627-640.

PMID: 37708242 PMC: 11197145. DOI: 10.1177/0271678X231201472.

Sex Differences in Resilience and Resistance to Brain Pathology and Dysfunction Moderated by Cerebrovascular Response to Exercise and Genetic Risk for Alzheimer's Disease.

Palmer J, Kaufman C, Vidoni E, Honea R, Burns J, Billinger S J Alzheimers Dis. 2022; 90(2):535-542.

PMID: 36155505 PMC: 9731318. DOI: 10.3233/JAD-220359.

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