Significant Associations Between AXIN1 Rs1805105, Rs12921862, Rs370681 Haplotypes and Variant Genotypes of AXIN2 Rs2240308 with Risk of Congenital Heart Defects

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2020 Oct 24

PMID 33096676

Citations 1

Authors

George Andrei Crauciuc

Mihaela Iancu

Peter Olah

Florin Tripon

Madalina Anciuc

Liliana Gozar

Rodica Toganel

Claudia Banescu

Affiliations

Soon will be listed here.

Abstract

This study aimed to investigate possible associations of the susceptibility to congenital heart defects (CHDs) with rs1805105, rs12921862 and rs370681 gene variants and haplotypes and rs2240308 gene variant. Significant associations were identified for rs370681 and rs2240308 variants. rs370681 variant was significantly associated with decreased odds of CHDs (adjusted OR varying from 0.13 to 0.28 in codominant, dominant and recessive gene models), while the rs2240308 variant was associated with increased odds of CHD in the dominant model. The haplotype-based generalized linear model regression of rs1805105, rs12921862 and rs370681 variants revealed that C-C-C and C-C-T haplotypes significantly increased the risk of CHDs ( < 0.05). No significant second order epistatic interactions were found between investigated variants ( rs1805105, rs12921862, rs370681, and rs2240308). Our conclusion is that rs1805105, rs12921862, and rs370681 (C-C-C and C-C-T) haplotypes and rs2240308 contribute to CHDs susceptibility.

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