Evaluation of Success Rate of Lesion Sterilization and Tissue Repair Compared to Vitapex in Pulpally Involved Primary Teeth: A Systematic Review

Overview

Journal J Conserv Dent

Specialty Dentistry

Date 2020 Oct 22

PMID 33088056

Citations 4

Authors

Smital R Agarwal

Vikas D Bendgude

Pradnya Kakodkar

Affiliations

Soon will be listed here.

Abstract

Background: Vitapex has been a popular obturating material for several decades. In recent times, lesion sterilization and tissue repair (LSTR) has shown promising results. This technique uses a mixture of 3 antibiotics for sterilization of the root canals and healing of periradicular tissues.

Objective: The objective of this systematic review was to compile all the literature comparing Vitapex and LSTR for pulpally involved primary teeth and evaluate the success rate in terms of clinical and radiographic outcomes.

Materials And Methods: This review is based on PRISMA guidelines. The electronic search on MEDLINE via PubMed database and Google scholar, cross-referencing and hand search of journals was carried out for articles from January 1, 2000 to December 31, 2019. Articles only in the English language were selected. Out of the 17 articles, 3 unique articles were identified for the review, of which 2 were randomized controlled trials and 1 was a retrospective study.

Results: All the three articles were assessed for their quality and all had a low risk of bias. It was found that LSTR and Vitapex had a high clinical success after 12 months. The radiographic success after 6 months was high but decreased after 12 months in both the groups.

Conclusion: There is no difference in the success rate of LSTR as compared to Vitapex for the treatment of pulpally involved primary teeth.

Citing Articles

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3Mixtatin versus MTA in pulp therapy of primary teeth: a systematic review and meta-analysis of current randomized controlled trials.

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Almarji W, Laflouf M, Alsayed Tolibah Y Clin Exp Dent Res. 2024; 10(2):e860.

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Minocycline hydrochloride ointment combined with Vitapex paste is effective for middle-aged and elderly patients with combined periodontal-endodontic lesions.

Zeng Z, Zeng Z, Wu G Am J Transl Res. 2024; 16(1):314-322.

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Hu R, Zhang F, Guo X, Jing Y, Lin X, Tian L Comput Math Methods Med. 2022; 2022:7540961.

PMID: 35813417 PMC: 9270133. DOI: 10.1155/2022/7540961.

References

RIFKIN A . A simple, effective, safe technique for the root canal treatment of abscessed primary teeth. ASDC J Dent Child. 1980; 47(6):435-41. View

Ozalp N, Saroglu I, Sonmez H . Evaluation of various root canal filling materials in primary molar pulpectomies: an in vivo study. Am J Dent. 2006; 18(6):347-50. View

Trairatvorakul C, Detsomboonrat P . Success rates of a mixture of ciprofloxacin, metronidazole, and minocycline antibiotics used in the non-instrumentation endodontic treatment of mandibular primary molars with carious pulpal involvement. Int J Paediatr Dent. 2011; 22(3):217-27. DOI: 10.1111/j.1365-263X.2011.01181.x. View

Takushige T, Cruz E, Asgor Moral A, Hoshino E . Endodontic treatment of primary teeth using a combination of antibacterial drugs. Int Endod J. 2004; 37(2):132-8. DOI: 10.1111/j.0143-2885.2004.00771.x. View

Pinky C, Shashibhushan K, Subbareddy V . Endodontic treatment of necrosed primary teeth using two different combinations of antibacterial drugs: an in vivo study. J Indian Soc Pedod Prev Dent. 2011; 29(2):121-7. DOI: 10.4103/0970-4388.84684. View

Fuks A . Pulp therapy for the primary and young permanent dentitions. Dent Clin North Am. 2000; 44(3):571-96, vii. View

Hoelscher A, Bahcall J, Maki J . In vitro evaluation of the antimicrobial effects of a root canal sealer-antibiotic combination against Enterococcus faecalis. J Endod. 2006; 32(2):145-7. DOI: 10.1016/j.joen.2005.10.031. View

Doneria D, Thakur S, Singhal P, Chauhan D, Keshav K, Uppal A . In Search of a Novel Substitute: Clinical and Radiological Success of Lesion Sterilization and Tissue Repair with Modified 3Mix-MP Antibiotic Paste and Conventional Pulpectomy for Primary Molars with Pulp Involvement with 18 Months Follow-up. Contemp Clin Dent. 2018; 8(4):514-521. PMC: 5754969. DOI: 10.4103/ccd.ccd_47_17. View

Slim K, Nini E, Forestier D, Kwiatkowski F, Panis Y, Chipponi J . Methodological index for non-randomized studies (minors): development and validation of a new instrument. ANZ J Surg. 2003; 73(9):712-6. DOI: 10.1046/j.1445-2197.2003.02748.x. View

10.

Prabhakar A, Sridevi E, Raju O, Satish V . Endodontic treatment of primary teeth using combination of antibacterial drugs: an in vivo study. J Indian Soc Pedod Prev Dent. 2008; 26 Suppl 1:S5-10. View

11.

Holan G, Fuks A . A comparison of pulpectomies using ZOE and KRI paste in primary molars: a retrospective study. Pediatr Dent. 1993; 15(6):403-7. View

12.

Nakornchai S, Banditsing P, Visetratana N . Clinical evaluation of 3Mix and Vitapex as treatment options for pulpally involved primary molars. Int J Paediatr Dent. 2010; 20(3):214-21. DOI: 10.1111/j.1365-263X.2010.01044.x. View

13.

Nurko C, Ranly D, Garcia-Godoy F, Lakshmyya K . Resorption of a calcium hydroxide/iodoform paste (Vitapex) in root canal therapy for primary teeth: a case report. Pediatr Dent. 2001; 22(6):517-20. View

14.

Nurko C, Garcia-Godoy F . Evaluation of a calcium hydroxide/iodoform paste (Vitapex) in root canal therapy for primary teeth. J Clin Pediatr Dent. 1999; 23(4):289-94. View

15.

Mortazavi M, Mesbahi M . Comparison of zinc oxide and eugenol, and Vitapex for root canal treatment of necrotic primary teeth. Int J Paediatr Dent. 2004; 14(6):417-24. DOI: 10.1111/j.1365-263X.2004.00544.x. View

16.

Nanda R, Koul M, Srivastava S, Upadhyay V, Dwivedi R . Clinical evaluation of 3 Mix and Other Mix in non-instrumental endodontic treatment of necrosed primary teeth. J Oral Biol Craniofac Res. 2015; 4(2):114-9. PMC: 4252383. DOI: 10.1016/j.jobcr.2014.08.003. View

17.

Moss S, ADDELSTON H, Goldsmith E . HISTOLOGIC STUDY OF PULPAL FLOOR OF DECIDUOUS MOLARS. J Am Dent Assoc. 1965; 70:372-9. DOI: 10.14219/jada.archive.1965.0296. View

18.

Kubota K, Golden B, Penugonda B . Root canal filling materials for primary teeth: a review of the literature. ASDC J Dent Child. 1992; 59(3):225-7. View