Genome Stability and MtDNA Variants in Field Populations Eight Years After Release

Overview

Journal iScience

Publisher Cell Press

Date 2020 Oct 21

PMID 33083739

Citations 13

Authors

Bixing Huang

Qiong Yang

Ary A Hoffmann

Scott A Ritchie

Andrew F van den Hurk

David Warrilow

Affiliations

Soon will be listed here.

Abstract

A dengue suppression strategy based on release of mosquitoes infected with the bacterium is being trialed in many countries. inhibits replication and transmission of dengue viruses. Questions remain regarding the long-term stability of virus-suppressive effects. We sequenced the genome and analyzed mitochondrial DNA markers isolated from mosquitoes sampled 2-8 years after releases in the greater Cairns region, Australia. Few changes were detected when genomes of field mosquitoes were compared with genomes of mosquitoes obtained soon after initial releases. Mitochondrial variants associated with the initial release stock are now the only variants found in release sites, highlighting maternal leakage as a possible explanation for rare -negative mosquitoes and not migration from non-release areas. There is no evidence of changes in the genome that indicate selection against its viral-suppressive effects or other phenotypes attributable to infection with the bacterium.

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