The Transcription Factor Sox10 is an Essential Determinant of Branching Morphogenesis and Involution in the Mouse Mammary Gland

Overview

Journal Sci Rep

Specialty Science

Date 2020 Oct 21

PMID 33082503

Citations 10

Authors

Svenja Mertelmeyer

Matthias Weider

Tina Baroti

Simone Reiprich

Franziska Frob

C Claus Stolt

Kay-Uwe Wagner

Michael Wegner

Affiliations

Soon will be listed here.

Abstract

The high mobility group-domain containing transcription factor Sox10 is an essential regulator of developmental processes and homeostasis in the neural crest, several neural crest-derived lineages and myelinating glia. Recent studies have also implicated Sox10 as an important factor in mammary stem and precursor cells. Here we employ a series of mouse mutants with constitutive and conditional Sox10 deficiencies to show that Sox10 has multiple functions in the developing mammary gland. While there is no indication for a requirement of Sox10 in the specification of the mammary placode or descending mammary bud, it is essential for both the prenatal hormone-independent as well as the pubertal hormone-dependent branching of the mammary epithelium and for proper alveologenesis during pregnancy. It furthermore acts in a dosage-dependent manner. Sox10 also plays a role during the involution process at the end of the lactation period. Whereas its effect on epithelial branching and alveologenesis are likely causally related to its function in mammary stem and precursor cells, this is not the case for its function during involution where Sox10 seems to work at least in part through regulation of the miR-424(322)/503 cluster.

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