Adipokines and Inflammation: Focus on Cardiovascular Diseases

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Oct 21

PMID 33081064

Citations 32

Authors

Sandra Feijoo-Bandin

Alana Aragon-Herrera

Sandra Morana-Fernandez

Laura Anido-Varela

Estefania Tarazon

Esther Rosello-Lleti

Manuel Portoles

Isabel Moscoso

Oreste Gualillo

Jose Ramon Gonzalez-Juanatey

Francisca Lago

Affiliations

Soon will be listed here.

Abstract

It is well established that adipose tissue, apart from its energy storage function, acts as an endocrine organ that produces and secretes a number of bioactive substances, including hormones commonly known as adipokines. Obesity is a major risk factor for the development of cardiovascular diseases, mainly due to a low grade of inflammation and the excessive fat accumulation produced in this state. The adipose tissue dysfunction in obesity leads to an aberrant release of adipokines, some of them with direct cardiovascular and inflammatory regulatory functions. Inflammation is a common link between obesity and cardiovascular diseases, so this review will summarise the role of the main adipokines implicated in the regulation of the inflammatory processes occurring under the scenario of cardiovascular diseases.

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