Anti-biofilm FeO@C-[1,3,4]thiadiazolo[3,2-]pyrimidin-4-ium-2-thiolate Derivative Core-shell Nanocoatings

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2020 Oct 21

PMID 33080907

Citations 2

Authors

Rodica Olar

Mihaela Badea

Catalin Maxim

Alexandru Mihai Grumezescu

Coralia Bleotu

Luminita Marutescu

Mariana Carmen Chifiriuc

Affiliations

Soon will be listed here.

Abstract

The derivatives 5,7-dimethyl[1,3,4]thiadiazolo[3,2-]pyrimidin-4-ium-2-thiolate () and 7-methyl-5-phenyl[1,3,4]thiadiazolo[3,2-]pyrimidin-4-ium-2-thiolate () were fully characterized by single-crystal X-ray diffraction. Their supramolecular structure is built through both π-π stacking and C=S-π interactions for both compounds. The embedment of the tested compounds into FeO@C core-shell nanocoatings increased the protection degree against biofilms on the catheter surface, suggesting that these bioactive nanocoatings could be further developed as non-cytotoxic strategies for fighting biofilm-associated fungal infections.

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