Force-of-infection of Taenia Solium Porcine Cysticercosis: a Modelling Analysis to Assess Global Incidence and Prevalence Trends

Overview

Journal Sci Rep

Specialty Science

Date 2020 Oct 20

PMID 33077748

Citations 4

Authors

Matthew A Dixon

Peter Winskill

Wendy E Harrison

Charles Whittaker

Veronika Schmidt

Elsa Sarti

Saw Bawm

Michel M Dione

Lian F Thomas

Martin Walker

Maria-Gloria Basanez

Affiliations

Soon will be listed here.

Abstract

The World Health Organization (WHO) called, in 2012, for a validated strategy towards Taenia solium taeniasis/cysticercosis control and elimination. Estimating pig force-of-infection (FoI, the average rate at which susceptible pigs become infected) across geographical settings will help understand local epidemiology and inform effective intervention design. Porcine cysticercosis (PCC) age-prevalence data (from 15 studies in Latin America, Africa and Asia) were identified through systematic review. Catalytic models were fitted to the data using Bayesian methods, incorporating uncertainty in diagnostic performance, to estimate rates of antibody seroconversion, viable metacestode acquisition, and seroreversion/infection loss. There was evidence of antibody seroreversion across 5 studies, and of infection loss in 6 studies measured by antigen or necropsy, indicating transient serological responses and natural resolution of infection. Concerted efforts should be made to collect robust data using improved diagnostics to better understand geographical heterogeneities in T. solium transmission to support post-2020 WHO targets.

Citing Articles

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