Clinical Characteristics of COVID-19 Patients with HIV Coinfection in Wuhan, China

Overview

Journal Expert Rev Respir Med

Specialty Pulmonary Medicine

Date 2020 Oct 19

PMID 33074039

Citations 11

Authors

Rongrong Yang

Xien Gui

Yongxi Zhang

Yong Xiong

Shicheng Gao

Hengning Ke

Affiliations

Soon will be listed here.

Abstract

Background: Information about the impact of HIV coinfection on clinical characteristics of COVID-19 patients remains limited.

Methods: Maximum body temperatures, fever duration, chest CT and viral shedding, lymphocyte counts, and titer of SARS-CoV-2 antibody were compared between COVID-19 patients with and without HIV infection in Zhongnan Hospital of Wuhan University from January 20th to February 14th, 2020.

Results: Compared with 53 COVID-19 patients without HIV infection, the patients with SARS-CoV-2 and HIV coinfection had higher maximum body temperatures (38.7°C vs 37.6°C, = 0.044), longer duration of fever (8.7 ± 4.5 vs 4.2 ± 2.1 days, = 0.038), longer time to have improvement of chest CT images (22 vs 15 days from the onset of illness, = 0.011), lower level of SARS-CoV-2 IgG (5.11 ± 32.33 vs 37.45 ± 15.48 AU/ml, = 0.042). However, no statistically significant difference of duration of SARS-CoV-2 shedding in the two groups was found (12.3 ± 2.6 vs 13.4 ± 2.4 days, , = 0.813).

Conclusion: Lower level of CD4 T lymphocyte counts caused by HIV infection itself might be one of reasons for relatively weak ability to produce SARS-CoV-2 specific antibodies. The effects of anti-HIV drugs in prevention and treatment of COVID-19 appears to be limited.

Citing Articles

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