Maltotriose Conjugated Metal-Organic Frameworks for Selective Targeting and Photodynamic Therapy of Triple Negative Breast Cancer Cells and Tumor Associated Macrophages

Overview

Journal Adv Ther (Weinh)

Date 2020 Oct 19

PMID 33072859

Citations 4

Authors

Yoshie Sakamaki

John Ozdemir

Alda Diaz Perez

Zachary Heidrick

Olivia Watson

Miu Tsuji

Chirstopher Salmon

Joseph Batta-Mpouma

Anthony Azzun

Valerie Lomonte

Yuchun Du

Julie Stenken

Jin Woo-Kim

M Hassan Beyzavi

Affiliations

Soon will be listed here.

Abstract

Herein, we report a nano-MOF conjugated to maltotriose as a new DDS. MA-PCN-224-0.1Mn/0.9Zn showed its ability to target cancer and TAM. This novel MOF is an effective PDT agent and shows little dark toxicity, MA-PCN-224-0.1Mn/0.9Zn uptakes selectively into cancer cells. A well-suited size control methodology was used so that the nano-scaled MOFs may take advantage of the EPR effect. This development of a nano-scale MOF for PDT that is conjugated to a cancer targeting ligand represents a meaningful development for the use of MOFs as drug delivery systems.

Citing Articles

Multifunctional nanostructures: Intelligent design to overcome biological barriers.

Azizi M, Jahanban-Esfahlan R, Samadian H, Hamidi M, Seidi K, Dolatshahi-Pirouz A Mater Today Bio. 2023; 20:100672.

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Antitumor therapy for breast cancer: Focus on tumor-associated macrophages and nanosized drug delivery systems.

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Current Photoactive Molecules for Targeted Therapy of Triple-Negative Breast Cancer.

Dias C, Helguero L, Faustino M Molecules. 2021; 26(24).

PMID: 34946732 PMC: 8709347. DOI: 10.3390/molecules26247654.

A Bio-Conjugated Chlorin-Based Metal-Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers.

Sakamaki Y, Ozdemir J, Heidrick Z, Azzun A, Watson O, Tsuji M ACS Appl Bio Mater. 2021; 4(2):1432-1440.

PMID: 34337346 PMC: 8320713. DOI: 10.1021/acsabm.0c01324.

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