Galectin-3 As a Therapeutic Target for NSAID-Induced Intestinal Ulcers

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2020 Oct 19

PMID 33072090

Citations 6

Authors

Ah-Mee Park

Sundar Khadka

Fumitaka Sato

Seiichi Omura

Mitsugu Fujita

Daniel K Hsu

Fu-Tong Liu

Ikuo Tsunoda

Affiliations

Soon will be listed here.

Abstract

Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03832946.

Citing Articles

Galectins and Liver Diseases.

Mimura S, Morishita A, Oura K, Takuma K, Nakahara M, Tadokoro T Int J Mol Sci. 2025; 26(2).

PMID: 39859504 PMC: 11766161. DOI: 10.3390/ijms26020790.

Rescue of mitochondrial dysfunction through alteration of extracellular matrix composition in barth syndrome cardiac fibroblasts.

Pineiro-Llanes J, Suzuki-Hatano S, Jain A, Venigalla S, Kamat M, Basso K Biomaterials. 2024; 315:122922.

PMID: 39509858 PMC: 11625619. DOI: 10.1016/j.biomaterials.2024.122922.

Link between mutations in and genes and chronic intestinal ulcers: A case report and review of literature.

Tang Y, Zhang J, Wang J, Tian R, Zhong W, Yao B World J Gastrointest Surg. 2024; 16(3):932-943.

PMID: 38577076 PMC: 10989323. DOI: 10.4240/wjgs.v16.i3.932.

The Role of Galectin-3 in Retinal Degeneration and Other Ocular Diseases: A Potential Novel Biomarker and Therapeutic Target.

Zhou Z, Feng Z, Sun X, Wang Y, Dou G Int J Mol Sci. 2023; 24(21).

PMID: 37958500 PMC: 10649114. DOI: 10.3390/ijms242115516.

NSAID-Associated Small Intestinal Injury: An Overview From Animal Model Development to Pathogenesis, Treatment, and Prevention.

Zhang M, Xia F, Xia S, Zhou W, Zhang Y, Han X Front Pharmacol. 2022; 13:818877.

PMID: 35222032 PMC: 8864225. DOI: 10.3389/fphar.2022.818877.

References

Chan Y, Lin H, Tu Z, Kuo Y, Hsu S, Lin C . Dissecting the Structure-Activity Relationship of Galectin-Ligand Interactions. Int J Mol Sci. 2018; 19(2). PMC: 5855614. DOI: 10.3390/ijms19020392. View

Barondes S, Cooper D, Gitt M, Leffler H . Galectins. Structure and function of a large family of animal lectins. J Biol Chem. 1994; 269(33):20807-10. View

Darnaud M, Dos Santos A, Gonzalez P, Augui S, Lacoste C, Desterke C . Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis. Gastroenterology. 2017; 154(4):1009-1023.e14. DOI: 10.1053/j.gastro.2017.11.003. View

McCoy K, Geuking M, Ronchi F . Gut Microbiome Standardization in Control and Experimental Mice. Curr Protoc Immunol. 2017; 117:23.1.1-23.1.13. DOI: 10.1002/cpim.25. View

Grabinger T, Garzon J, Hausmann M, Geirnaert A, Lacroix C, Hennet T . Alleviation of Intestinal Inflammation by Oral Supplementation With 2-Fucosyllactose in Mice. Front Microbiol. 2019; 10:1385. PMC: 6593069. DOI: 10.3389/fmicb.2019.01385. View

MacKinnon A, Gibbons M, Farnworth S, Leffler H, Nilsson U, Delaine T . Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3. Am J Respir Crit Care Med. 2011; 185(5):537-46. PMC: 3410728. DOI: 10.1164/rccm.201106-0965OC. View

Osaka T, Moriyama E, Arai S, Date Y, Yagi J, Kikuchi J . Meta-Analysis of Fecal Microbiota and Metabolites in Experimental Colitic Mice during the Inflammatory and Healing Phases. Nutrients. 2017; 9(12). PMC: 5748779. DOI: 10.3390/nu9121329. View

Davies N, Saleh J, Skjodt N . Detection and prevention of NSAID-induced enteropathy. J Pharm Pharm Sci. 2000; 3(1):137-55. View

Weissenborn U, Maedge S, BUETTNER D, SEWING K . Indometacin-induced gastrointestinal lesions in relation to tissue concentration, food intake and bacterial invasion in the rat. Pharmacology. 1985; 30(1):32-9. DOI: 10.1159/000138047. View

10.

Park A, Hagiwara S, Hsu D, Liu F, Yoshie O . Galectin-3 Plays an Important Role in Innate Immunity to Gastric Infection by Helicobacter pylori. Infect Immun. 2016; 84(4):1184-1193. PMC: 4807496. DOI: 10.1128/IAI.01299-15. View

11.

Beatty W, Rhoades E, Hsu D, Liu F, Russell D . Association of a macrophage galactoside-binding protein with Mycobacterium-containing phagosomes. Cell Microbiol. 2002; 4(3):167-76. DOI: 10.1046/j.1462-5822.2002.00183.x. View

12.

Bjarnason I, Hayllar J, Macpherson A, Russell A . Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology. 1993; 104(6):1832-47. DOI: 10.1016/0016-5085(93)90667-2. View

13.

Dabek M, McCrae S, Stevens V, Duncan S, Louis P . Distribution of beta-glucosidase and beta-glucuronidase activity and of beta-glucuronidase gene gus in human colonic bacteria. FEMS Microbiol Ecol. 2008; 66(3):487-95. DOI: 10.1111/j.1574-6941.2008.00520.x. View

14.

Takeuchi K, Tanaka A, Ohno R, Yokota A . Role of COX inhibition in pathogenesis of NSAID-induced small intestinal damage. J Physiol Pharmacol. 2004; 54 Suppl 4:165-82. View

15.

Fukumoto K, Naito Y, Takagi T, Yamada S, Horie R, Inoue K . Role of tumor necrosis factor-α in the pathogenesis of indomethacin-induced small intestinal injury in mice. Int J Mol Med. 2011; 27(3):353-9. DOI: 10.3892/ijmm.2011.602. View

16.

Magierowski M, Jasnos K, Kwiecien S, Drozdowicz D, Surmiak M, Strzalka M . Endogenous prostaglandins and afferent sensory nerves in gastroprotective effect of hydrogen sulfide against stress-induced gastric lesions. PLoS One. 2015; 10(3):e0118972. PMC: 4361614. DOI: 10.1371/journal.pone.0118972. View

17.

Nair A, Jacob S . A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm. 2016; 7(2):27-31. PMC: 4804402. DOI: 10.4103/0976-0105.177703. View

18.

Kohatsu L, Hsu D, Jegalian A, Liu F, Baum L . Galectin-3 induces death of Candida species expressing specific beta-1,2-linked mannans. J Immunol. 2006; 177(7):4718-26. DOI: 10.4049/jimmunol.177.7.4718. View

19.

Kato Y, Hiasa M, Ichikawa R, Hasuzawa N, Kadowaki A, Iwatsuki K . Identification of a vesicular ATP release inhibitor for the treatment of neuropathic and inflammatory pain. Proc Natl Acad Sci U S A. 2017; 114(31):E6297-E6305. PMC: 5547629. DOI: 10.1073/pnas.1704847114. View

20.

Farnworth S, Henderson N, MacKinnon A, Atkinson K, Wilkinson T, Dhaliwal K . Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function. Am J Pathol. 2008; 172(2):395-405. PMC: 2312371. DOI: 10.2353/ajpath.2008.070870. View