Oxytocin Receptor Signaling in Vascular Function and Stroke

Overview

Journal Front Neurosci

Date 2020 Oct 19

PMID 33071746

Citations 11

Authors

Erin C McKay

Scott E Counts

Affiliations

Soon will be listed here.

Abstract

The oxytocin receptor (OXTR) is a G protein-coupled receptor with a diverse repertoire of intracellular signaling pathways, which are activated in response to binding oxytocin (OXT) and a similar nonapeptide, vasopressin. This review summarizes the cell and molecular biology of the OXTR and its downstream signaling cascades, particularly focusing on the vasoactive functions of OXTR signaling in humans and animal models, as well as the clinical applications of OXTR targeting cerebrovascular accidents.

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References

Di Benedetto A, Sun L, Zambonin C, Tamma R, Nico B, Calvano C . Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor. Proc Natl Acad Sci U S A. 2014; 111(46):16502-7. PMC: 4246276. DOI: 10.1073/pnas.1419349111. View

Stoop R . Neuromodulation by oxytocin and vasopressin. Neuron. 2012; 76(1):142-59. DOI: 10.1016/j.neuron.2012.09.025. View

Grotegut C, Mao L, Pierce S, Swamy G, Heine R, Murtha A . Enhanced Uterine Contractility and Stillbirth in Mice Lacking G Protein-Coupled Receptor Kinase 6 (GRK6): Implications for Oxytocin Receptor Desensitization. Mol Endocrinol. 2016; 30(4):455-68. PMC: 4814475. DOI: 10.1210/me.2015-1147. View

Lozic M, Sarenac O, Murphy D, Japundzic-Zigon N . Vasopressin, Central Autonomic Control and Blood Pressure Regulation. Curr Hypertens Rep. 2018; 20(2):11. DOI: 10.1007/s11906-018-0811-0. View

Huber D, Veinante P, Stoop R . Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science. 2005; 308(5719):245-8. DOI: 10.1126/science.1105636. View

Grazzini E, Guillon G, Mouillac B, Zingg H . Inhibition of oxytocin receptor function by direct binding of progesterone. Nature. 1998; 392(6675):509-12. DOI: 10.1038/33176. View

Luttrell L, Ferguson S, Daaka Y, Miller W, Maudsley S, Della Rocca G . Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 1999; 283(5402):655-61. DOI: 10.1126/science.283.5402.655. View

Gregory S, Connelly J, Towers A, Johnson J, Biscocho D, Markunas C . Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Med. 2009; 7:62. PMC: 2774338. DOI: 10.1186/1741-7015-7-62. View

Robinson C, Schumann R, Zhang P, Young R . Oxytocin-induced desensitization of the oxytocin receptor. Am J Obstet Gynecol. 2003; 188(2):497-502. DOI: 10.1067/mob.2003.22. View

10.

Garrott K, Dyavanapalli J, Cauley E, Dwyer M, Kuzmiak-Glancy S, Wang X . Chronic activation of hypothalamic oxytocin neurons improves cardiac function during left ventricular hypertrophy-induced heart failure. Cardiovasc Res. 2017; 113(11):1318-1328. PMC: 5852539. DOI: 10.1093/cvr/cvx084. View

11.

Oppong-Damoah A, Zaman R, DSouza M, Murnane K . Nanoparticle encapsulation increases the brain penetrance and duration of action of intranasal oxytocin. Horm Behav. 2018; 108:20-29. PMC: 7001472. DOI: 10.1016/j.yhbeh.2018.12.011. View

12.

Choi D, Kim J, Lee K, Kim H, Kim Y, Choi W . Role of neuronal NADPH oxidase 1 in the peri-infarct regions after stroke. PLoS One. 2015; 10(1):e0116814. PMC: 4305324. DOI: 10.1371/journal.pone.0116814. View

13.

Ninan I . Oxytocin suppresses basal glutamatergic transmission but facilitates activity-dependent synaptic potentiation in the medial prefrontal cortex. J Neurochem. 2011; 119(2):324-31. DOI: 10.1111/j.1471-4159.2011.07430.x. View

14.

Nazari A, Sadr S, Faghihi M, Azizi Y, Hosseini M, Mobarra N . Vasopressin attenuates ischemia-reperfusion injury via reduction of oxidative stress and inhibition of mitochondrial permeability transition pore opening in rat hearts. Eur J Pharmacol. 2015; 760:96-102. DOI: 10.1016/j.ejphar.2015.04.006. View

15.

Lee S, Park S, Chung C, Kim J, Choi S, Han J . Oxytocin Protects Hippocampal Memory and Plasticity from Uncontrollable Stress. Sci Rep. 2015; 5:18540. PMC: 4685249. DOI: 10.1038/srep18540. View

16.

Benovic J, Kuhn H, Weyand I, CODINA J, Caron M, Lefkowitz R . Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). Proc Natl Acad Sci U S A. 1987; 84(24):8879-82. PMC: 299654. DOI: 10.1073/pnas.84.24.8879. View

17.

Erkanli K, Erkanli Senturk G, Aydin U, Arbak S, Ercan F, Tuncdemir M . Oxytocin protects rat skeletal muscle against ischemia/reperfusion injury. Ann Vasc Surg. 2013; 27(5):662-70. DOI: 10.1016/j.avsg.2012.10.012. View

18.

Gutkowska J, Jankowski M, Lambert C, Mukaddam-Daher S, Zingg H, McCANN S . Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart. Proc Natl Acad Sci U S A. 1997; 94(21):11704-9. PMC: 23602. DOI: 10.1073/pnas.94.21.11704. View

19.

Szeto A, Rossetti M, Mendez A, Noller C, Herderick E, Gonzales J . Oxytocin administration attenuates atherosclerosis and inflammation in Watanabe Heritable Hyperlipidemic rabbits. Psychoneuroendocrinology. 2012; 38(5):685-93. PMC: 3543511. DOI: 10.1016/j.psyneuen.2012.08.009. View

20.

Busnelli M, Chini B . Molecular Basis of Oxytocin Receptor Signalling in the Brain: What We Know and What We Need to Know. Curr Top Behav Neurosci. 2017; 35:3-29. DOI: 10.1007/7854_2017_6. View