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Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms

Overview
Journal Int J Mol Sci
Publisher MDPI
Date 2020 Oct 17
PMID 33066029
Citations 365
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Abstract

Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. Its pathophysiology comprises acute and chronic phases and incorporates a cascade of destructive events such as ischemia, oxidative stress, inflammatory events, apoptotic pathways and locomotor dysfunctions. Many therapeutic strategies have been proposed to overcome neurodegenerative events and reduce secondary neuronal damage. Efforts have also been devoted in developing neuroprotective and neuro-regenerative therapies that promote neuronal recovery and outcome. Although varying degrees of success have been achieved, curative accomplishment is still elusive probably due to the complex healing and protective mechanisms involved. Thus, current understanding in this area must be assessed to formulate appropriate treatment modalities to improve SCI recovery. This review aims to promote the understanding of SCI pathophysiology, interrelated or interlinked multimolecular interactions and various methods of neuronal recovery i.e., neuroprotective, immunomodulatory and neuro-regenerative pathways and relevant approaches.

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References
1.
Lalkovicova M, Danielisova V . Neuroprotection and antioxidants. Neural Regen Res. 2016; 11(6):865-74. PMC: 4962567. DOI: 10.4103/1673-5374.184447. View

2.
Orihuela R, McPherson C, Harry G . Microglial M1/M2 polarization and metabolic states. Br J Pharmacol. 2015; 173(4):649-65. PMC: 4742299. DOI: 10.1111/bph.13139. View

3.
Gerber Y, Privat A, Perrin F . Gacyclidine improves the survival and reduces motor deficits in a mouse model of amyotrophic lateral sclerosis. Front Cell Neurosci. 2014; 7:280. PMC: 3873512. DOI: 10.3389/fncel.2013.00280. View

4.
Mustafa A, Wang J, Carrico K, Hall E . Pharmacological inhibition of lipid peroxidation attenuates calpain-mediated cytoskeletal degradation after traumatic brain injury. J Neurochem. 2011; 117(3):579-88. PMC: 3076544. DOI: 10.1111/j.1471-4159.2011.07228.x. View

5.
Jensen S, Michaels N, Ilyntskyy S, Keough M, Kovalchuk O, Yong V . Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1α. Cell Rep. 2018; 24(12):3167-3179. DOI: 10.1016/j.celrep.2018.08.060. View