Ventro-dorsal Hippocampal Pathway Gates Novelty-Induced Contextual Memory Formation

Overview

Journal Curr Biol

Publisher Cell Press

Specialty Biology

Date 2020 Oct 16

PMID 33065009

Citations 27

Authors

Felipe Fredes

Maria Alejandra Silva

Peter Koppensteiner

Kenta Kobayashi

Maximilian Joesch

Ryuichi Shigemoto

Affiliations

Soon will be listed here.

Abstract

Novelty facilitates memory formation and is detected by both the dorsal and ventral hippocampus. Although dentate granule cells (GCs) in the dorsal hippocampus are known to mediate the formation of novelty-induced contextual memories, the required pathways and mechanisms remain unclear. Here we demonstrate that a powerful excitatory pathway from mossy cells (MCs) in the ventral hippocampus to dorsal GCs is necessary and sufficient for driving dorsal GC activation in novel environment exploration. In vivo Ca imaging in freely moving mice indicated that this pathway relays environmental novelty. Furthermore, manipulation of ventral MC activity bidirectionally regulates novelty-induced contextual memory acquisition. Our results show that ventral MC activity gates contextual memory formation through an intra-hippocampal interaction activated by environmental novelty.

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