Biomedical Application of Reactive Oxygen Species-Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases

Overview

Journal Front Chem

Specialty Chemistry

Date 2020 Oct 16

PMID 33062637

Citations 15

Authors

Jinggong Liu

Yongjin Li

Song Chen

Yongpeng Lin

Haoqiang Lai

Bolai Chen

Tianfeng Chen

Affiliations

Soon will be listed here.

Abstract

Numerous pathological conditions, including cancer, inflammatory diseases, and neurodegenerative diseases, are accompanied by overproduction of reactive oxygen species (ROS). This makes ROS vital flagging molecules in disease pathology. ROS-responsive drug delivery platforms have been developed. Nanotechnology has been broadly applied in the field of biomedicine leading to the progress of ROS-responsive nanoparticles. In this review, we focused on the production and physiological/pathophysiological impact of ROS. Particular emphasis is put on the mechanisms and effects of abnormal ROS levels on oxidative stress diseases, including cancer, inflammatory disease, and neurodegenerative diseases. Finally, we summarized the potential biomedical applications of ROS-responsive nanocarriers in these oxidative stress diseases. We provide insights that will help in the designing of new ROS-responsive nanocarriers for various applications.

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References

Xiang J, Liu X, Zhou Z, Zhu D, Zhou Q, Piao Y . Reactive Oxygen Species (ROS)-Responsive Charge-Switchable Nanocarriers for Gene Therapy of Metastatic Cancer. ACS Appl Mater Interfaces. 2018; 10(50):43352-43362. DOI: 10.1021/acsami.8b13291. View

Grzelczak M, Liz-Marzan L, Klajn R . Stimuli-responsive self-assembly of nanoparticles. Chem Soc Rev. 2019; 48(5):1342-1361. DOI: 10.1039/c8cs00787j. View

Forman H, Torres M . Redox signaling in macrophages. Mol Aspects Med. 2001; 22(4-5):189-216. DOI: 10.1016/s0098-2997(01)00010-3. View

Harman D . Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956; 11(3):298-300. DOI: 10.1093/geronj/11.3.298. View

Chung M, Chia W, Wan W, Lin Y, Sung H . Controlled Release of an Anti-inflammatory Drug Using an Ultrasensitive ROS-Responsive Gas-Generating Carrier for Localized Inflammation Inhibition. J Am Chem Soc. 2015; 137(39):12462-5. DOI: 10.1021/jacs.5b08057. View

Imlay J . Pathways of oxidative damage. Annu Rev Microbiol. 2003; 57:395-418. DOI: 10.1146/annurev.micro.57.030502.090938. View

Qiu M, Wang D, Liang W, Liu L, Zhang Y, Chen X . Novel concept of the smart NIR-light-controlled drug release of black phosphorus nanostructure for cancer therapy. Proc Natl Acad Sci U S A. 2018; 115(3):501-506. PMC: 5776980. DOI: 10.1073/pnas.1714421115. View

Clark R . Activation of the neutrophil respiratory burst oxidase. J Infect Dis. 1999; 179 Suppl 2:S309-17. DOI: 10.1086/513849. View

Guo C, Sun L, Chen X, Zhang D . Oxidative stress, mitochondrial damage and neurodegenerative diseases. Neural Regen Res. 2014; 8(21):2003-14. PMC: 4145906. DOI: 10.3969/j.issn.1673-5374.2013.21.009. View

10.

Dou Y, Chen Y, Zhang X, Xu X, Chen Y, Guo J . Non-proinflammatory and responsive nanoplatforms for targeted treatment of atherosclerosis. Biomaterials. 2017; 143:93-108. DOI: 10.1016/j.biomaterials.2017.07.035. View

11.

Ray P, Huang B, Tsuji Y . Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal. 2012; 24(5):981-90. PMC: 3454471. DOI: 10.1016/j.cellsig.2012.01.008. View

12.

Bolduc J, Collins J, Loeser R . Reactive oxygen species, aging and articular cartilage homeostasis. Free Radic Biol Med. 2018; 132:73-82. PMC: 6342625. DOI: 10.1016/j.freeradbiomed.2018.08.038. View

13.

Liu Y, Ai K, Ji X, Askhatova D, Du R, Lu L . Comprehensive Insights into the Multi-Antioxidative Mechanisms of Melanin Nanoparticles and Their Application To Protect Brain from Injury in Ischemic Stroke. J Am Chem Soc. 2016; 139(2):856-862. PMC: 5752099. DOI: 10.1021/jacs.6b11013. View

14.

Folgueras A, Pendas A, Sanchez L, Lopez-Otin C . Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies. Int J Dev Biol. 2004; 48(5-6):411-24. DOI: 10.1387/ijdb.041811af. View

15.

Giorgio M, Trinei M, Migliaccio E, Pelicci P . Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?. Nat Rev Mol Cell Biol. 2007; 8(9):722-8. DOI: 10.1038/nrm2240. View

16.

Hsu H, Wen M . Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression. J Biol Chem. 2002; 277(25):22131-9. DOI: 10.1074/jbc.M111883200. View

17.

Wang L, Fan F, Cao W, Xu H . Ultrasensitive ROS-Responsive Coassemblies of Tellurium-Containing Molecules and Phospholipids. ACS Appl Mater Interfaces. 2015; 7(29):16054-60. DOI: 10.1021/acsami.5b04419. View

18.

Geng J, Li M, Wu L, Chen C, Qu X . Mesoporous silica nanoparticle-based H2O2 responsive controlled-release system used for Alzheimer's disease treatment. Adv Healthc Mater. 2012; 1(3):332-6. DOI: 10.1002/adhm.201200067. View

19.

Tapeinos C, Pandit A . Physical, Chemical, and Biological Structures based on ROS-Sensitive Moieties that are Able to Respond to Oxidative Microenvironments. Adv Mater. 2016; 28(27):5553-85. DOI: 10.1002/adma.201505376. View

20.

Nathan C, Cunningham-Bussel A . Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nat Rev Immunol. 2013; 13(5):349-61. PMC: 4250048. DOI: 10.1038/nri3423. View