ACTH-Independent Cushing's Syndrome Associated with Left Adrenocortical Oncocytoma of Uncertain Malignant Potential

Overview

Journal Case Rep Endocrinol

Publisher Wiley

Specialty Endocrinology

Date 2020 Oct 16

PMID 33062350

Citations 1

Authors

Giuseppe S Sica

Leandro Siragusa

Bruno Sensi

Vittoria Bellato

Pierangela Floris

Valentina Rovella

Alessandro Mauriello

Monia Di Prete

Rossana Telesca

Valerio Ciavoni

Carmine Cardillo

Nicola Di Daniele

Manfredi Tesauro

Affiliations

Soon will be listed here.

Abstract

Adrenocortical oncocytomas are rare and mostly nonfunctioning neoplasms. We report the case of a 27-year-old woman diagnosed with an ACTH-independent Cushing's syndrome due to left adrenal oncocytoma. She underwent laparoscopic adrenalectomy. Histopathological examination revealed an oncocytoma of uncertain malignant potential with a low Ki-67 proliferation index, inhibin A positivity, and chromogranin A negativity. Electron micrographs confirmed adrenal oncocytoma cells, characterized by the presence of a large amount of mitochondria. The postoperative course was uneventful, and the patient experienced a progressive regression of Cushing-related symptoms. Periodical follow-ups with MRI and cortisol dosage are required due to the neoplasm's uncertain malignant potential. Considerations on the diagnosis, pathology findings, clinical remarks, and interventions are made.

Citing Articles

Oncocytic adrenocortical neoplasm with undetermined malignant potential and autonomous cortisol secretion.

San Juan M, Lagamayo D, Carnate J, Joven M BMJ Case Rep. 2022; 15(4).

PMID: 35444021 PMC: 9021750. DOI: 10.1136/bcr-2021-248525.

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