Qidonghuoxue Decoction Ameliorates Pulmonary Edema in Acute Lung Injury Mice Through the Upregulation of Epithelial Sodium Channel and Aquaporin-1

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2020 Oct 16

PMID 33062004

Citations 5

Authors

Chunfang Ma

Lei Dong

Minjing Li

Wanru Cai

Affiliations

Soon will be listed here.

Abstract

QDHX decoction is an effective traditional Chinese medicine that has been used to treat ALI, a disease characterized by pulmonary edema and inflammation. In this study, the aim is to elucidate the molecular mechanisms of QDHX decoction on improving the alveolar-capillary membrane permeability and alleviating inflammatory response. The BALB/c mice were divided into five groups including the control group, ALI group, ALI + low-dose QDHX decoction, ALI + high-dose QDHX decoction, and ALI + dexamethasone. When the animals were sacrificed, the pathology and wet/dry of lung tissue were tested and confirmed Ali model, the LDH and nucleated cells in BALF, and TNF- and IL-1 in serum; -ENaC and AQP-1 in lung tissue were examined. In the results, QDHX decoction downregulated the cytokine such as TNF- and IL-1, reduced the nucleated cells, and some biochemical parameters of the BALF. It also ameliorated the ENaC- and AQP-1 expression induced by LPS in primary epithelial cells. These findings may provide new insights into the application of QDHX decoction for the prevention and treatment of LPS-related ALI.

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