The Perspective of Diagnostic and Prognostic Values of Lipoxygenases MRNA Expression in Colon Adenocarcinoma

Overview

Journal Onco Targets Ther

Publisher Dove Medical Press

Specialty Oncology

Date 2020 Oct 16

PMID 33061426

Citations 9

Authors

Guo-Tian Ruan

Yi-Zhen Gong

Li-Chen Zhu

Feng Gao

Xi-Wen Liao

Xiang-Kun Wang

Guang-Zhi Zhu

Cun Liao

Shuai Wang

Ling Yan

Hai-Lun Xie

Xin Zhou

Jun-Qi Liu

Meng-Nan Shao

Jia-Liang Gan

Affiliations

Soon will be listed here.

Abstract

Background: This study was mainly to explore and study the potential application of lipoxygenases (ALOX) family genes in the diagnostic and prognostic values of colon adenocarcinoma (COAD).

Methods: Data sets related to the ALOX genes of COAD were obtained from The Cancer Genome Atlas and the University of California, Santa Cruz Xena browser. Then, the relevant biological information was downloaded from the public data platform. Finally, the bioinformatics technologies and clinical verification were employed to comprehensively analyze the potential values of ALOX genes.

Results: The Pearson correlation analysis indicated that there were correlations among , , , and . The diagnostic receiver operating characteristic (ROC) curves suggested that and had significant diagnosis in COAD: <0.001, area under curve (AUC) 95%CI:=0.818 (0.773-0.862) and ; <0.001, AUC 95%CI=0.774 (0.682-0.807). Besides, the verification study indicated that had a diagnostic value in COAD. Finally, our multivariate survival analysis and comprehensive prognosis of ALOX genes in COAD suggested that the and were associated with COAD overall survival: ; =0.025, HR 95%CI=1.765 (1.074-2.901), ; =0.046, HR 95%CI=1.680 (1.009-2.796), and the low expression of and had a favorable prognosis of COAD (all <0.05); on the contrary, the high regulation of them increased the risk of death.

Conclusion: In our study, we observed that the mRNA expressions of ALOX genes were associated with the diagnosis and prognosis of COAD. The results of the diagnostic analysis suggested that might have a diagnosis value in COAD. Besides, our comprehensive prognosis analysis indicated that combined might serve as potential prognosis biomarkers for COAD.

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