Combined Analysis of Deletions and Expression on Prognostic Impact in Pediatric B-cell Precursor Acute Lymphoblastic Leukemia

This study aimed to investigate the combined impact of deletions/high expression of on the prognosis of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). deletions and expression were assessed in bone marrow samples from 117 children with newly diagnosed BCP-ALL. Sixteen (13.7%) patients were found to harbor deletions, which was associated with inferior outcomes. The event-free survival (EFS) for patients with high - expression was significantly worse than that for low - expression. Moreover, combined modeling of / identified 7.8% of cases as the highest risk subgroup (7-year EFS 33.3 ± 15.7%). In a multivariate analysis, / remained a strong independent prognostic factor for EFS (HR: 14.263,  = 0.019). deletions and high - expression were associated with inferior outcomes, and the coexistence of / had a significant impact on an integrated prognostic model for high-risk BCP-ALL.