Substance-P Restores Cellular Activity of ADSC Impaired by Oxidative Stress

Overview

Journal Antioxidants (Basel)

Date 2020 Oct 15

PMID 33053897

Citations 6

Authors

Jeong Seop Park

Jiyuan Piao

Gabee Park

Hyun Sook Hong

Affiliations

Soon will be listed here.

Abstract

Oxidative stress induces cellular damage, which accelerates aging and promotes the development of serious illnesses. Adipose-derived stem cells (ADSCs) are novel cellular therapeutic tools and have been applied for tissue regeneration. However, ADSCs from aged and diseased individuals may be affected in vivo by the accumulation of free radicals, which can impair their therapeutic efficacy. Substance-P (SP) is a neuropeptide that is known to rescue stem cells from senescence and inflammatory attack, and this study explored the restorative effect of SP on ADSCs under oxidative stress. ADSCs were transiently exposed to HO, and then treated with SP. HO treatment decreased ADSC cell viability, proliferation, and cytokine production and this activity was not recovered even after the removal of HO. However, the addition of SP increased cell viability and restored paracrine potential, leading to the accelerated repopulation of ADSCs injured by HO. Furthermore, SP was capable of activating Akt/GSK-3β signaling, which was found to be downregulated following HO treatment. This might contribute to the restorative effect of SP on injured ADSCs. Collectively, SP can protect ADSCs from oxidant-induced cell damage, possibly by activating Akt/GSK-3β signaling in ADSCs. This study supports the possibility that SP can recover cell activity from oxidative stress-induced dysfunction.

Citing Articles

Substance P-Mediated Vascular Protection Ameliorates Bone Loss.

Kim D, Piao J, Park J, Lee D, Hwang D, Hong H Oxid Med Cell Longev. 2023; 2023:9903336.

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Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway.

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Lee D, Park J, Kim D, Hong H Antioxidants (Basel). 2022; 11(5).

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Metformin attenuates HO-induced osteoblast apoptosis by regulating SIRT3 via the PI3K/AKT pathway.

Yang K, Pei L, Zhou S, Tao L, Zhu Y Exp Ther Med. 2021; 22(5):1316.

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