Evolution of an Inducible Penicillin-target Protein in Methicillin-resistant Staphylococcus Aureus by Gene Fusion

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 1987 Aug 31

PMID 3305073

Citations 124

Authors

M D Song

M Wachi

M Doi

F Ishino

M Matsuhashi

Affiliations

Soon will be listed here.

Abstract

A new beta-lactam-inducible penicillin-binding protein (PBP) that has extremely low affinity to penicillin and most other beta-lactam antibiotics has been widely found in highly beta-lactam(methicillin)-resistant Staphylococcus aureus (MRSA). The gene for this protein was sequenced and the nucleotide sequence in its promoter and close upstream area was found to show close similarity with that of staphylococcal penicillinase, while the amino acid sequence over a wide range of the molecule was found to be similar to those of two PBPs of Escherichia coli, the shape-determining protein (PBP 2) and septum-forming one (PBP 3). Probably the MRSA PBP (Mr 76462) evolved by recombination of two genes: an inducible type I penicillinase gene and a PBP gene of a bacterium, causing the formation of a beta-lactam-inducible MRSA PBP.

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