Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Oct 14

PMID 33050668

Citations 16

Authors

Wenji Zhang

Yingyi Lian

Qiuhua Li

Lingli Sun

Ruohong Chen

Xingfei Lai

Zhaoxiang Lai

Erdong Yuan

Shili Sun

Affiliations

Soon will be listed here.

Abstract

Peptic ulcer disease is a common gastrointestinal tract disorder that affects up to 20% of the population of the world. Treatment of peptic ulcer remains challenging due to the limited effectiveness and severe side effects of the currently available drugs. Hence, natural compounds, owing to their medicinal, ecological, and other safe properties, are becoming popular potential candidates in preventing and treating peptic ulcers. Flavonoids, the most abundant polyphenols in plants, exhibit gastroprotective effects against peptic ulcer both in vivo and in vitro. In this review, we summarized the anti-ulcer functions and mechanisms, and also the bioavailability, efficacy, and safety, of flavonoid monomers in the gastrointestinal tract. Flavonoids exerted cytoprotective and rehabilitative effects by not only strengthening defense factors, such as mucus and prostaglandins, but also protecting against potentially harmful factors via their antioxidative, anti-inflammatory, and antibacterial activities. Although controlled clinical studies are limited at present, flavonoids have shown a promising preventable and therapeutic potential in peptic ulcers.

Citing Articles

Gastroprotective properties of flavonoid-rich extract of against ethanol-induced gastric ulcer in mice.

Boudebbaz K, Brouk M, Laalem R, Zabaiou N Heliyon. 2025; 11(1):e41625.

PMID: 39866446 PMC: 11758829. DOI: 10.1016/j.heliyon.2025.e41625.

Gastroprotective Efficacy of North African Medicinal Plants: A Review on Their Therapeutic Potential for Peptic Ulcers.

Cherrada N, Chemsa A, Gheraissa N, Laib I, Gueboudji Z, El-Shazly M Food Sci Nutr. 2024; 12(11):8793-8824.

PMID: 39619964 PMC: 11606823. DOI: 10.1002/fsn3.4536.

Comparison of Dietary Supplementation with Krill Oil, Fish Oil, and Astaxanthin on an Experimental Ethanol-Induced Gastric Ulcer Model: A Biochemical and Histological Study.

Sariyer E, Bas M, Colak H, Ozkan Yenal N, Unay Demirel O, Yuksel M Nutrients. 2024; 16(20).

PMID: 39458422 PMC: 11510526. DOI: 10.3390/nu16203426.

Troxerutin effect on gastric ulcers induced by ketorolac in rats: Relation with oxidative stress.

Darkazally A, Alnour A, Homsi S Heliyon. 2024; 10(19):e38893.

PMID: 39435065 PMC: 11492593. DOI: 10.1016/j.heliyon.2024.e38893.

Histopathological and biochemical evaluation of the protective efficacy of L. extract in a rat model of indomethacin-induced gastric ulcer.

Cetin N, Menevse E, Ceylan C, Celik Z, Akdam N, Rama S Iran J Basic Med Sci. 2024; 27(11):1464-1474.

PMID: 39386230 PMC: 11459347. DOI: 10.22038/ijbms.2024.78382.16941.

References

Malfertheiner P, Megraud F, OMorain C, Gisbert J, Kuipers E, Axon A . Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut. 2016; 66(1):6-30. DOI: 10.1136/gutjnl-2016-312288. View

Raffa D, Maggio B, Raimondi M, Plescia F, Daidone G . Recent discoveries of anticancer flavonoids. Eur J Med Chem. 2017; 142:213-228. DOI: 10.1016/j.ejmech.2017.07.034. View

Nagao M, Morita N, Yahagi T, Shimizu M, Kuroyanagi M, Fukuoka M . Mutagenicities of 61 flavonoids and 11 related compounds. Environ Mutagen. 1981; 3(4):401-19. DOI: 10.1002/em.2860030402. View

Mates J, Perez-Gomez C, Nunez de Castro I . Antioxidant enzymes and human diseases. Clin Biochem. 2000; 32(8):595-603. DOI: 10.1016/s0009-9120(99)00075-2. View

Allen A, Flemstrom G . Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell Physiol. 2004; 288(1):C1-19. DOI: 10.1152/ajpcell.00102.2004. View

Lanas A . Role of nitric oxide in the gastrointestinal tract. Arthritis Res Ther. 2008; 10 Suppl 2:S4. PMC: 2582807. DOI: 10.1186/ar2465. View

Lanas A, Chan F . Peptic ulcer disease. Lancet. 2017; 390(10094):613-624. DOI: 10.1016/S0140-6736(16)32404-7. View

Amato A, Terzo S, Mule F . Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer's Disease. Antioxidants (Basel). 2019; 8(12). PMC: 6943487. DOI: 10.3390/antiox8120608. View

Liu Y, Gou L, Fu X, Li S, Lan N, Yin X . Protective effect of rutin against acute gastric mucosal lesions induced by ischemia-reperfusion. Pharm Biol. 2013; 51(7):914-9. DOI: 10.3109/13880209.2013.771375. View

10.

Hu X, Ding C, Zhou N, Xu C . Quercetin protects gastric epithelial cell from oxidative damage in vitro and in vivo. Eur J Pharmacol. 2015; 754:115-24. DOI: 10.1016/j.ejphar.2015.02.007. View

11.

Kim S, Park J, Sung G, Yang S, Yang W, Kim E . Kaempferol, a dietary flavonoid, ameliorates acute inflammatory and nociceptive symptoms in gastritis, pancreatitis, and abdominal pain. Mol Nutr Food Res. 2015; 59(7):1400-5. DOI: 10.1002/mnfr.201400820. View

12.

Nagula R, Wairkar S . Recent advances in topical delivery of flavonoids: A review. J Control Release. 2019; 296:190-201. DOI: 10.1016/j.jconrel.2019.01.029. View

13.

Fallone C, Chiba N, Veldhuyzen Van Zanten S, Fischbach L, Gisbert J, Hunt R . The Toronto Consensus for the Treatment of Helicobacter pylori Infection in Adults. Gastroenterology. 2016; 151(1):51-69.e14. DOI: 10.1053/j.gastro.2016.04.006. View

14.

Cohen A . Critical review of the toxicology of coumarin with special reference to interspecies differences in metabolism and hepatotoxic response and their significance to man. Food Cosmet Toxicol. 1979; 17(3):277-89. DOI: 10.1016/0015-6264(79)90289-x. View

15.

Khan M, Khundmiri S, Khundmiri S, Al-Sanea M, Mok P . Fruit-Derived Polysaccharides and Terpenoids: Recent Update on the Gastroprotective Effects and Mechanisms. Front Pharmacol. 2018; 9:569. PMC: 6024987. DOI: 10.3389/fphar.2018.00569. View

16.

Ryan S, McNicholas W, Taylor C . A critical role for p38 map kinase in NF-kappaB signaling during intermittent hypoxia/reoxygenation. Biochem Biophys Res Commun. 2007; 355(3):728-33. DOI: 10.1016/j.bbrc.2007.02.015. View

17.

Sato H, Matsui T, Arakawa Y . The protective effect of catechin on gastric mucosal lesions in rats, and its hormonal mechanisms. J Gastroenterol. 2002; 37(2):106-11. DOI: 10.1007/s005350200004. View

18.

Carrasco-Pozo C, Morales P, Gotteland M . Polyphenols protect the epithelial barrier function of Caco-2 cells exposed to indomethacin through the modulation of occludin and zonula occludens-1 expression. J Agric Food Chem. 2013; 61(22):5291-7. DOI: 10.1021/jf400150p. View

19.

Moon S, Lee J, Kim K, Park Y, Nah S, Ahn D . Antimicrobial effect of 7-O-butylnaringenin, a novel flavonoid, and various natural flavonoids against Helicobacter pylori strains. Int J Environ Res Public Health. 2013; 10(11):5459-69. PMC: 3863854. DOI: 10.3390/ijerph10115459. View

20.

Crofford L, Tan B, McCarthy C, Hla T . Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes. Arthritis Rheum. 1997; 40(2):226-36. DOI: 10.1002/art.1780400207. View