Role of CD4 T Cells in Allergic Airway Diseases: Learning from Murine Models

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Oct 14

PMID 33050549

Citations 10

Authors

Kento Miura

Kimiko Inoue

Atsuo Ogura

Osamu Kaminuma

Affiliations

Soon will be listed here.

Abstract

The essential contribution of CD4 T cells in allergic airway diseases has been demonstrated, especially by using various murine models of antigen-induced airway inflammation. In addition to antigen-immunized mouse models employing mast cell-deficient mice and CD4 T cell-depleting procedure, antigen-specific CD4 T cell transfer models have revealed the possible development of allergic inflammation solely dependent on CD4 T cells. Regardless of the classical Th1/Th2 theory, various helper T cell subsets have the potential to induce different types of allergic inflammation. T cell receptor (TCR)-transgenic (Tg) mice have been used for investigating T cell-mediated immune responses. Besides, we have recently generated cloned mice from antigen-specific CD4 T cells through somatic cell nuclear transfer. In contrast to TCR-Tg mice that express artificially introduced TCR, the cloned mice express endogenously regulated antigen-specific TCR. Upon antigen exposure, the mite antigen-reactive T cell-cloned mice displayed strong airway inflammation accompanied by bronchial hyperresponsiveness in a short time period. Antigen-specific CD4 T cell-cloned mice are expected to be useful for investigating the detailed role of CD4 T cells in various allergic diseases and for evaluating novel anti-allergic drugs.

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