» Articles » PMID: 33049277

HOX Genes and the NF-κB Pathway: A Convergence of Developmental Biology, Inflammation and Cancer Biology

Overview
Publisher Elsevier
Date 2020 Oct 13
PMID 33049277
Citations 25
Authors
Affiliations
Soon will be listed here.
Abstract

The roles of HOX transcription factors as oncogenes and tumor suppressor genes, and the NF-KB pathway in chronic inflammation, both leading to cancer are well-established. HOX transcription factors are members of an evolutionarily conserved family of proteins required for anteroposterior body axis patterning during embryonic development, and are often dysregulated in cancer. The NF-KB pathway aids inflammation and immunity but it is also important during embryonic development. It is frequently activated in both solid and hematological malignancies. NF-KB and HOX proteins can influence each other through mutual transcriptional regulation, protein-protein interactions, and regulation of upstream and downstream interactors. These interactions have important implications both in homeostasis and in disease. In this review, we summarize the role of HOX proteins in regulating inflammation in homeostasis and disease- with a particular emphasis on cancer. We also describe the relationship between HOX genes and the NF-KB pathway, and discuss potential therapeutic strategies.

Citing Articles

Expression of Dlx-5 and HLX Proteins in Odontogenic Cysts.

Ates S, Topaloglu U, Akbalik M, Keles Karagozoglu S Life (Basel). 2025; 15(2).

PMID: 40003710 PMC: 11857689. DOI: 10.3390/life15020301.


Laparoscopic Salpingectomy Regulates The Expression of Endometrial Homeobox Genes () and HOX Transcript Antisense Intergenic RNA in Women with Communicating Hydrosalpinx: A Prospective Study.

Zafarani F, Mehranjani M, Ghaffari F, Shahhoseini M, Shariatzadeh S Int J Fertil Steril. 2024; 18(4):344-351.

PMID: 39564825 PMC: 11589967. DOI: 10.22074/ijfs.2024.2026081.1655.


Molecular Mechanism of Radioresponsiveness in Colorectal Cancer: A Systematic Review.

Lau M, Islam Khan M, Law H Genes (Basel). 2024; 15(10).

PMID: 39457381 PMC: 11508137. DOI: 10.3390/genes15101257.


The role of NF-κB-SOX9 signalling pathway in osteoarthritis.

Tian B, Zhang L, Zheng J, Kang X Heliyon. 2024; 10(17):e37191.

PMID: 39319133 PMC: 11419907. DOI: 10.1016/j.heliyon.2024.e37191.


The role of NF-kappaB in the inflammatory processes related to dental caries, pulpitis, apical periodontitis, and periodontitis-a narrative review.

Chen Z, Lang G, Xu X, Liang X, Han Y, Han Y PeerJ. 2024; 12:e17953.

PMID: 39221277 PMC: 11366231. DOI: 10.7717/peerj.17953.