Corilagin Reduces Acetaminophen-induced Hepatotoxicity Through MAPK and NF-B Signaling Pathway in a Mouse Model

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2020 Oct 12

PMID 33042441

Citations 16

Authors

Fu-Chao Liu

Huang-Ping Yu

An-Hsun Chou

Hung-Chen Lee

Chia-Chih Liao

Affiliations

Soon will be listed here.

Abstract

Corilagin is a major active polyphenolic tannins extracted from , an important herb used in traditional medicine. Previous reports demonstrated that corilagin possesses antioxidant and anti-inflammatory properties. Therefore, this study aimed to evaluate its hepatoprotective effects and mechanisms on acetaminophen (APAP)-induced liver injury in mice. Mice included in this study were intraperitoneally injected with a hepatotoxic APAP dose (300 mg/kg). After a 30 min of APAP administration, corilagin was injected intraperitoneally at concentrations of 0, 1, 5, 10, and 20 mg/kg. Then, after 16 h of corilagin treatment, mice were sacrificed for further analysis. APAP overdose significantly elevated the serum ALT level, hepatic myeloperoxidase (MPO) activity, cytokines (TNF-α, IL-1β, and IL-6) production, malondialdehyde (MDA) activity, and ERK/JNK MAPK and NF-κB protein expressions. Corilagin treatment significantly decreased these parameters in a dose-dependent manner (1-20 mg/kg). This study demonstrated that corilagin may be a potential therapeutic target for the prevention of APAP-induced hepatotoxicity by down-regulating the inflammatory response and by inhibiting ERK/JNK MAPK and NF-κB signaling pathways.

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