Silencing MicroRNA-181a-5p Suppresses Malignant Behavior of Lacrimal Adenoid Cystic Carcinoma Cells by Upregulating Large Tumor Suppressor 2

Overview

Journal Int J Clin Exp Pathol

Specialty Pathology

Date 2020 Oct 12

PMID 33042355

Citations 2

Authors

Rongrong Fu

Yingshuang Wang

Yawen Wang

Affiliations

Soon will be listed here.

Abstract

To uncover the effect of miR-181a-5p regulating large tumor suppressor 2 (LATS2) in biologic processes of adenoid cystic carcinoma (ACC) cells, miR-181a-5p and LATS2 expression in lacrimal ACC (LACC) tissues were assessed. The ACC cell lines were respectively treated with altered miR-181a-5p or LATS2 to determine the biologic functions in ACC cells. Binding ability of miR-181a-5p and LATS2 was confirmed. Tumor growth was assessed as well. MiR-181a-5p was upregulated while LATS2 was downregulated in LACC tissues. Reduced miR-181a-5p restrained malignant phenotype of ACC cells and decelerated xenograft growth. Conversely, LATS2 reduction had opposite effects compared to miR-181a-5p knockdown on ACC cells. Furthermore, downregulated LATS2 could abolish the alterations in ACC cells induced by miR-181a-5p silencing. MiR-181a-5p inhibition upregulated LATS2 to suppress malignant behavior of ACC cells and .

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