Circadian Genes As Therapeutic Targets in Pancreatic Cancer

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2020 Oct 12

PMID 33042011

Citations 13

Authors

Maria Garcia-Costela

Julia Escudero-Feliu

Jose D Puentes-Pardo

Sara Moreno San Juan

Sonia Morales-Santana

Sandra Rios-Arrabal

Angel Carazo

Josefa Leon

Affiliations

Soon will be listed here.

Abstract

Pancreatic cancer is one of the most lethal cancers worldwide due to its symptoms, early metastasis, and chemoresistance. Thus, the mechanisms contributing to pancreatic cancer progression require further exploration. Circadian rhythms are the daily oscillations of multiple biological processes regulated by an endogenous clock. Several evidences suggest that the circadian clock may play an important role in the cell cycle, cell proliferation and apoptosis. In addition, timing of chemotherapy or radiation treatment can influence the efficacy and toxicity treatment. Here, we revisit the studies on circadian clock as an emerging target for therapy in pancreatic cancer. We highlight those potential circadian genes regulators that are commonly affected in pancreatic cancer according to most recent reports.

Citing Articles

Abnormal Histopathological Expression of Klotho, Ferroptosis, and Circadian Clock Regulators in Pancreatic Ductal Adenocarcinoma: Prognostic Implications and Correlation Analyses.

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Cellular senescence and metabolic reprogramming: Unraveling the intricate crosstalk in the immunosuppressive tumor microenvironment.

Zhang F, Guo J, Yu S, Zheng Y, Duan M, Zhao L Cancer Commun (Lond). 2024; 44(9):929-966.

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The Relationship between Circadian Rhythm and Cancer Disease.

Munteanu C, Turti S, Achim L, Muresan R, Souca M, Prifti E Int J Mol Sci. 2024; 25(11).

PMID: 38892035 PMC: 11172077. DOI: 10.3390/ijms25115846.

The circadian rhythm: an influential soundtrack in the diabetes story.

Hariri A, Mirian M, Zarrabi A, Kohandel M, Amini-Pozveh M, Aref A Front Endocrinol (Lausanne). 2023; 14:1156757.

PMID: 37441501 PMC: 10333930. DOI: 10.3389/fendo.2023.1156757.

NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation.

Cobo I, Paliwal S, Bodas C, Felipe I, Melia-Aloma J, Torres A Nat Commun. 2023; 14(1):3761.

PMID: 37353485 PMC: 10290102. DOI: 10.1038/s41467-023-39291-x.

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