Hypoproteinemia is an Independent Risk Factor for the Prognosis of Severe COVID-19 Patients

Overview

Journal J Clin Biochem Nutr

Specialty Biochemistry

Date 2020 Oct 12

PMID 33041508

Citations 8

Authors

Liu Lin

Kaiyuan Hu

Shuijiang Cai

Xilong Deng

Xinning Shao

Ying Liang

Jigang Wang

Tianyu Zhong

Zhongwei Hu

Ming Lei

Affiliations

Soon will be listed here.

Abstract

Severe patients of the coronavirus disease 2019 (COVID-19) may progress rapidly to critical stage. This study aimed to identify factors useful for predicting the progress. 33 severe COVID-19 patients at the intensive care unit were included in this study. During treatment, 13 patients deteriorated and required further treatment for supporting organ function. The remaining 20 patients alleviated and were transferred to the general wards. The multivariate COX regression analyses showed that hypoproteinemia was an independent risk factor associated with deterioration of severe patients (HR, 0.763; 95% CI, 0.596 to 0.978; = 0.033). The restricted cubic spline indicated that when HR = 1, the corresponding value of albumin is 29.6 g/L. We used the cutoff of 29.6 g/L to divide these patients. Kaplan-Meier curves showed that the survival rate of the high-albumin group was higher than that of the low-albumin group. Therefore, hypoalbuminemia may be an independent risk factor to evaluate poor prognosis of severely patients with COVID-19, especially when albumin levels were below 29.6 g/L.

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