Synthetic Lethal Interactions of RECQ Helicases

Overview

Journal Trends Cancer

Publisher Cell Press

Specialty Oncology

Date 2020 Oct 12

PMID 33041245

Citations 18

Authors

Arindam Datta

Srijita Dhar

Sanket Awate

Robert M Brosh Jr

Affiliations

Soon will be listed here.

Abstract

DNA helicases have risen to the forefront as genome caretakers. Their prominent roles in chromosomal stability are demonstrated by the linkage of mutations in helicase genes to hereditary disorders with defects in DNA repair, the replication stress response, and/or transcriptional activation. Conversely, accumulating evidence suggests that DNA helicases in cancer cells have a network of pathway interactions such that codeficiency of some helicases and their genetically interacting proteins results in synthetic lethality (SL). Such genetic interactions may potentially be exploited for cancer therapies. We discuss the roles of RECQ DNA helicases in cancer, emphasizing some of the more recent developments in SL.

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