Effect of Pregnancy and HIV Infection on Detection of Latent TB Infection by Tuberculin Skin Test and QuantiFERON-TB Gold In-Tube Assay Among Women Living in a High TB and HIV Burden Setting

Overview

Journal Int J Infect Dis

Publisher Elsevier

Specialty Infectious Diseases

Date 2020 Oct 11

PMID 33039610

Citations 9

Authors

Mahlet Birku

Girmay Desalegn

Getachew Kassa

Aster Tsegaye

Markos Abebe

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the effect of pregnancy and Human immunodeficiency virus (HIV) infection on detection performances of tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube (QFTGIT) for the diagnosis of latent tuberculosis infection (LTBI) among women living in high TB and HIV endemic setting.

Method: A cross-sectional study was conducted among women with and without pregnancy and HIV infection. Three-hundred twenty women were enrolled in this study and were diagnosed using TST and QFTGIT for the detection of LTBI.

Results: Overall prevalence of LTBI among the enrolled women was 55.6%, 46.3% and 51.1% as determined by TST, QFTGIT and concordant TST/QFTGIT results, respectively. Our study revealed that pregnancy or HIV infection reduced the rate of detection of LTBI by TST and QFTGIT tests, with the utmost effect observed in HIV-positive pregnant women. Additionally, we observed that the concordance between TST and QFTGIT among women increased with the presence of pregnancy and/or HIV infection. A history of contact with TB patients was significantly associated with positivity of TST and QFTGIT.

Conclusion: This study demonstrated that both pregnancy and HIV infection profoundly affected the detection performance of TST and QFTGIT, which may be associated with immunosuppression of anti-mycobacterial immunity in women with pregnancy and/or HIV infection.

Citing Articles

Discordance of 3rd and 4th generation QuantiFERON-TB Gold assays by pregnancy stages in India.

Kulkarni V, Alexander M, Bhosale R, Jain D, Deshpande P, Gitlin E J Clin Tuberc Other Mycobact Dis. 2025; 38:100504.

PMID: 39758562 PMC: 11697401. DOI: 10.1016/j.jctube.2024.100504.

Impact of exposure to HIV and latent TB on infant humoral responses.

Hjelmar K, de Armas L, Goldberg E, Pallikkuth S, Mathad J, Montepiedra G Front Immunol. 2024; 15:1423435.

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Impact of Human Immunodeficiency Virus and Peripartum Period on Mycobacterium tuberculosis Infection Detection.

Escudero J, Mecha J, Richardson B, Maleche-Obimbo E, Matemo D, Kinuthia J J Infect Dis. 2023; 228(12):1709-1719.

PMID: 37768184 PMC: 10733725. DOI: 10.1093/infdis/jiad416.

Determinants of QuantiFERON Plus-diagnosed tuberculosis infection in adult Ugandan TB contacts: A cross-sectional study.

Mayito J, Martineau A, Tiwari D, Nakiyingi L, Kateete D, Reece S PLoS One. 2023; 18(3):e0281559.

PMID: 36972254 PMC: 10042355. DOI: 10.1371/journal.pone.0281559.

Efficacy and Risk Factors of Interferon-Gamma Release Assays among HIV-Positive Individuals.

Qin H, Wang Y, Huang L, Huang Y, Ye J, Liang G Int J Environ Res Public Health. 2023; 20(5).

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