Signaling Pathways Involved in Environmental Sensing in Trypanosoma Cruzi

Overview

Journal Mol Microbiol

Specialties Microbiology
Molecular Biology

Date 2020 Oct 9

PMID 33034088

Citations 13

Authors

Noelia Lander

Miguel A Chiurillo

Roberto Docampo

Affiliations

Soon will be listed here.

Abstract

Trypanosoma cruzi is a unicellular parasite and the etiologic agent of Chagas disease. The parasite has a digenetic life cycle alternating between mammalian and insect hosts, where it faces a variety of environmental conditions to which it must adapt in order to survive. The adaptation to these changes is mediated by signaling pathways that coordinate the cellular responses to the new environmental settings. Major environmental changes include temperature, nutrient availability, ionic composition, pH, osmolarity, oxidative stress, contact with host cells and tissues, host immune response, and intracellular life. Some of the signaling pathways and second messengers potentially involved in the response to these changes have been elucidated in recent years and will be the subject of this review.

Citing Articles

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Carlson J, Ahmed M, Hunter R, Hoque S, Benoit J, Chiurillo M bioRxiv. 2024; .

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Adhesion of promotes a rapid change in developmental fate driven by cAMP signaling.

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A key regulator of male gametogenesis in Cryptosporidium.

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Transcriptomic analysis of N-terminal mutated Trypanosoma cruzi UBP1 knockdown underlines the importance of this RNA-binding protein in parasite development.

Sabalette K, Campo V, Sotelo-Silveira J, Smircich P, De Gaudenzi J PLoS Negl Trop Dis. 2024; 18(5):e0012179.

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A sticky situation: When trypanosomatids attach to insect tissues.

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