Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Overview

Journal J Cancer Prev

Specialty Oncology

Date 2020 Oct 9

PMID 33033708

Citations 15

Authors

Rohini Gomathinayagam

Ji Hee Ha

Muralidharan Jayaraman

Yong Sang Song

Ciro Isidoro

Danny N Dhanasekaran

Affiliations

Soon will be listed here.

Abstract

Thymoquinone (TQ) is a bioactive component derived from the seeds of that are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis.

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References

Schneider-Stock R, Fakhoury I, Zaki A, El-Baba C, Gali-Muhtasib H . Thymoquinone: fifty years of success in the battle against cancer models. Drug Discov Today. 2013; 19(1):18-30. DOI: 10.1016/j.drudis.2013.08.021. View

Bolton J, Trush M, Penning T, Dryhurst G, Monks T . Role of quinones in toxicology. Chem Res Toxicol. 2000; 13(3):135-60. DOI: 10.1021/tx9902082. View

Wu X, Lippman S . An intermittent approach for cancer chemoprevention. Nat Rev Cancer. 2011; 11(12):879-85. DOI: 10.1038/nrc3167. View

Yoon M, Ha J, Lee M, Chi S . Structure and apoptotic function of p73. BMB Rep. 2014; 48(2):81-90. PMC: 4352617. DOI: 10.5483/bmbrep.2015.48.2.255. View

Li F, Rajendran P, Sethi G . Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway. Br J Pharmacol. 2010; 161(3):541-54. PMC: 2990154. DOI: 10.1111/j.1476-5381.2010.00874.x. View

Pang J, Shen N, Yan F, Zhao N, Dou L, Wu L . Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells. Oncotarget. 2017; 8(21):34453-34467. PMC: 5470982. DOI: 10.18632/oncotarget.16431. View

Acharya B, Chatterjee A, Ganguli A, Bhattacharya S, Chakrabarti G . Thymoquinone inhibits microtubule polymerization by tubulin binding and causes mitotic arrest following apoptosis in A549 cells. Biochimie. 2013; 97:78-91. DOI: 10.1016/j.biochi.2013.09.025. View

Korbecki J, Baranowska-Bosiacka I, Gutowska I, Chlubek D . The effect of reactive oxygen species on the synthesis of prostanoids from arachidonic acid. J Physiol Pharmacol. 2013; 64(4):409-21. View

Pflaum J, Schlosser S, Muller M . p53 Family and Cellular Stress Responses in Cancer. Front Oncol. 2014; 4:285. PMC: 4204435. DOI: 10.3389/fonc.2014.00285. View

10.

Qadi S, Hassan M, Sheikh R, Baothman O, Zamzami M, Choudhry H . Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms. Epigenet Insights. 2019; 12:2516865719839011. PMC: 6452588. DOI: 10.1177/2516865719839011. View

11.

Sethi G, Ahn K, Aggarwal B . Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis. Mol Cancer Res. 2008; 6(6):1059-70. DOI: 10.1158/1541-7786.MCR-07-2088. View

12.

Abusnina A, Alhosin M, Keravis T, Muller C, Fuhrmann G, Bronner C . Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis. Cell Signal. 2010; 23(1):152-60. DOI: 10.1016/j.cellsig.2010.08.015. View

13.

Koka P, Mondal D, Schultz M, Abdel-Mageed A, Agrawal K . Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species. Exp Biol Med (Maywood). 2010; 235(6):751-60. DOI: 10.1258/ebm.2010.009369. View

14.

Zubair H, Khan H, Sohail A, Azim S, Ullah M, Ahmad A . Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: putative anticancer mechanism of antioxidants. Cell Death Dis. 2013; 4:e660. PMC: 3698541. DOI: 10.1038/cddis.2013.172. View

15.

Shoieb A, Elgayyar M, Dudrick P, Bell J, Tithof P . In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone. Int J Oncol. 2002; 22(1):107-13. View

16.

Badr G, Lefevre E, Mohany M . Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis. PLoS One. 2011; 6(9):e23741. PMC: 3164673. DOI: 10.1371/journal.pone.0023741. View

17.

Vidoni C, Ferraresi A, Secomandi E, Vallino L, Dhanasekaran D, Isidoro C . Epigenetic targeting of autophagy for cancer prevention and treatment by natural compounds. Semin Cancer Biol. 2019; 66:34-44. DOI: 10.1016/j.semcancer.2019.04.006. View

18.

Ashour A, Abd-Allah A, Korashy H, Attia S, Alzahrani A, Saquib Q . Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis. Mol Cell Biochem. 2014; 389(1-2):85-98. DOI: 10.1007/s11010-013-1930-1. View

19.

Arafa E, Zhu Q, Shah Z, Wani G, Barakat B, Racoma I . Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells. Mutat Res. 2010; 706(1-2):28-35. PMC: 3037029. DOI: 10.1016/j.mrfmmm.2010.10.007. View

20.

Woo C, Kumar A, Sethi G, Tan K . Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol. 2011; 83(4):443-51. DOI: 10.1016/j.bcp.2011.09.029. View