Saliva Diagnostic Utility in Patients with Type 2 Diabetes: Future Standard Method

Overview

Journal J Med Biochem

Specialty Biochemistry

Date 2020 Oct 9

PMID 33033445

Citations 7

Authors

Marwa Mrag

Asma Kassab

Asma Omezzine

Chebil Raoua Belkacem

Fredj Ismail Fatma Ben

Nabiha Douki

Kechrid Chedia Laouani

Ali Bouslema

Amor Faten Ben

Affiliations

Soon will be listed here.

Abstract

Background: The purpose of the present study was to assess saliva reliability in diagnosis and monitoring type 2 diabetes instead of blood.

Methods: Blood and unstimulated whole saliva were collected from 300 type 2 diabetic subjects and 300 healthy controls in fasting. Then, the salivary flow rate was calculated. All parameters including glucose, urea, amylase, total protein, albumin, C-reactive protein (CRP), immunoglobulin A (IgA), potassium, calcium and chloride were assessed in the supernatant, using an autoanalyzer. Oral exam was conducted by a single examiner on full mouth excluding third molars. Statistical analysis was performed by the SPSS 20.0 version.

Results: Saliva screening showed that glucose, urea, amylase, total protein, potassium, calcium and chloride were significantly higher in patients compared to controls (p < 0.05). Whereas, the IgA level and salivary flow rate were significantly reduced in patients (p < 0.05). No significant difference was found in albumin and CRP levels (p > 0.05). There was a significant positive correlation between salivary and plasma glucose levels (r = 0.887, and r = 0.900, p < 0.001), as well as, salivary and blood urea (r = 0.586, and r = 0.688, p < 0.001) in patients and controls, respectively.

Conclusions: From this study, saliva could be suggested as a useful diagnostic tool for type 2 diabetes.

Citing Articles

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Shrestha S, Pokhrel S, Poudel A, Bhandari Bc S, Shakya M, Timilsina A Int J Anal Chem. 2022; 2022:1781613.

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