Geoffery Burnstock's Influence on the Evolution of P2X3 Receptor Pharmacology

Overview

Journal Purinergic Signal

Publisher Springer

Date 2020 Oct 8

PMID 33029713

Citations 6

Authors

Michael F Jarvis

Affiliations

Soon will be listed here.

Citing Articles

ATP, an attractive target for the treatment of refractory chronic cough.

Zhang M, Sykes D, Sadofsky L, Morice A Purinergic Signal. 2022; 18(3):289-305.

PMID: 35727480 PMC: 9209634. DOI: 10.1007/s11302-022-09877-z.

Mechanisms of ATP release in pain: role of pannexin and connexin channels.

Munoz M, Griffith T, Contreras J Purinergic Signal. 2021; 17(4):549-561.

PMID: 34792743 PMC: 8677853. DOI: 10.1007/s11302-021-09822-6.

P2X3 Receptor Ligands: Structural Features and Potential Therapeutic Applications.

Spinaci A, Buccioni M, Dal Ben D, Marucci G, Volpini R, Lambertucci C Front Pharmacol. 2021; 12:653561.

PMID: 33927627 PMC: 8076795. DOI: 10.3389/fphar.2021.653561.

Purines in Pain as a Gliopathy.

Magni G, Ceruti S Front Pharmacol. 2021; 12:649807.

PMID: 33790798 PMC: 8006436. DOI: 10.3389/fphar.2021.649807.

That was then, this is now: the development of our knowledge and understanding of P2 receptor subtypes.

Kennedy C Purinergic Signal. 2021; 17(1):9-23.

PMID: 33527235 PMC: 7954963. DOI: 10.1007/s11302-021-09763-0.

References

Burnstock G . P2X receptors in sensory neurones. Br J Anaesth. 2000; 84(4):476-88. DOI: 10.1093/oxfordjournals.bja.a013473. View

Gu J, Macdermott A . Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses. Nature. 1997; 389(6652):749-53. DOI: 10.1038/39639. View

Brake A, Schumacher M, Julius D . ATP receptors in sickness, pain and death. Chem Biol. 1996; 3(4):229-32. DOI: 10.1016/s1074-5521(96)90101-5. View

Burnstock G, Wood J . Purinergic receptors: their role in nociception and primary afferent neurotransmission. Curr Opin Neurobiol. 1996; 6(4):526-32. DOI: 10.1016/s0959-4388(96)80060-2. View

Abdulqawi R, Dockry R, Holt K, Layton G, McCarthy B, Ford A . P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study. Lancet. 2014; 385(9974):1198-205. DOI: 10.1016/S0140-6736(14)61255-1. View

Drury A, SZENT-GYORGYI A . The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. J Physiol. 1929; 68(3):213-37. PMC: 1402863. DOI: 10.1113/jphysiol.1929.sp002608. View

Burnstock G . Purinergic nerves. Pharmacol Rev. 1972; 24(3):509-81. View

Hutchison A, Webb R, OEI H, Ghai G, Zimmerman M, Williams M . CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity. J Pharmacol Exp Ther. 1989; 251(1):47-55. View

Jahr C, Jessell T . ATP excites a subpopulation of rat dorsal horn neurones. Nature. 1983; 304(5928):730-3. DOI: 10.1038/304730a0. View

10.

Mansoor S, Lu W, Oosterheert W, Shekhar M, Tajkhorshid E, Gouaux E . X-ray structures define human P2X(3) receptor gating cycle and antagonist action. Nature. 2016; 538(7623):66-71. PMC: 5161641. DOI: 10.1038/nature19367. View

11.

Burnstock G, Campbell G, Satchell D, Smythe A . Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. Br J Pharmacol. 1970; 40(4):668-88. PMC: 1702901. DOI: 10.1111/j.1476-5381.1970.tb10646.x. View

12.

Tsuda M, Koizumi S, Kita A, Shigemoto Y, Ueno S, Inoue K . Mechanical allodynia caused by intraplantar injection of P2X receptor agonist in rats: involvement of heteromeric P2X2/3 receptor signaling in capsaicin-insensitive primary afferent neurons. J Neurosci. 2000; 20(15):RC90. PMC: 6772519. View

13.

Tsuzuki K, Kondo E, Fukuoka T, Yi D, Tsujino H, Sakagami M . Differential regulation of P2X(3) mRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia. Pain. 2001; 91(3):351-360. DOI: 10.1016/S0304-3959(00)00456-5. View

14.

Driessen B, Reimann W, Selve N, Friderichs E, Bultmann R . Antinociceptive effect of intrathecally administered P2-purinoceptor antagonists in rats. Brain Res. 1994; 666(2):182-8. DOI: 10.1016/0006-8993(94)90770-6. View

15.

Gever J, Soto R, Henningsen R, Martin R, Hackos D, Panicker S . AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010; 160(6):1387-98. PMC: 2938810. DOI: 10.1111/j.1476-5381.2010.00796.x. View

16.

Jarvis M, Khakh B . ATP-gated P2X cation-channels. Neuropharmacology. 2008; 56(1):208-15. DOI: 10.1016/j.neuropharm.2008.06.067. View

17.

HAMILTON S, Wade A, McMahon S . The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. Br J Pharmacol. 1999; 126(1):326-32. PMC: 1565771. DOI: 10.1038/sj.bjp.0702258. View

18.

Coutts A, Jorizzo J, Eady R, Greaves M, Burnstock G . Adenosine triphosphate-evoked vascular changes in human skin: mechanism of action. Eur J Pharmacol. 1981; 76(4):391-401. DOI: 10.1016/0014-2999(81)90110-2. View

19.

Barclay J, Patel S, Dorn G, Wotherspoon G, Moffatt S, Eunson L . Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain. J Neurosci. 2002; 22(18):8139-47. PMC: 6758070. View

20.

Garceau D, Chauret N . BLU-5937: A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration. Pulm Pharmacol Ther. 2019; 56:56-62. DOI: 10.1016/j.pupt.2019.03.007. View