Solitary Peritoneal Metastasis of Gastrointestinal Stromal Tumor: A Case Report

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2020 Oct 7

PMID 33024403

Citations 2

Authors

Yoichi Sugiyama

Kensuke Shimbara

Masaru Sasaki

Mohei Kouyama

Tatsuya Tazaki

Shinya Takahashi

Atsushi Nakamitsu

Affiliations

Soon will be listed here.

Abstract

Background: A gastrointestinal stromal tumor (GIST) is a mesenchymal tumor of the gastrointestinal tract that is most commonly found in the stomach. Recurrence of GISTs mostly occurs in the liver or peritoneum, and in most cases, multiple metastases occur. As a solitary peritoneal metastasis is rare, an appropriate treatment strategy has not been established. Here, we report a case of solitary peritoneal metastasis after complete resection of gastric GIST.

Case Summary: A 76-year-old woman was diagnosed with stomach GIST and underwent laparoscopic local resection using the CLEAN-NET method. As the recurrence risk was intermediate, adjuvant imatinib therapy was not administered. Two years after surgery, routine computed tomography revealed an abdominal mass between the dorsal side of the right hepatic lobe and right kidney. Other imaging tests did not reveal any abnormalities. Laparoscopic observation showed that the tumor was located at the retroperitoneum, and intraperitoneal dissemination was not found. Therefore, we performed laparoscopic tumor resection. Immunohistochemically, the tumor was positive for c-kit and CD34 and had a relatively high mitotic index and MIB-1 Labeling index. We administered adjuvant imatinib therapy. There was no evidence of recurrence 3 years after the operation.

Conclusion: This is the first reported case of a solitary recurrence of GIST in the peritoneum treated with complete laparoscopic resection.

Citing Articles

Multi-slice spiral computed tomography in differential diagnosis of gastric stromal tumors and benign gastric polyps, and gastric stromal tumor risk stratification assessment.

Li X, Han P, Wang W, Shao L, Wang Y World J Gastrointest Oncol. 2022; 14(10):2004-2013.

PMID: 36310702 PMC: 9611439. DOI: 10.4251/wjgo.v14.i10.2004.

Current treatment strategies and future perspectives for gastrointestinal stromal tumors.

Sugiyama Y, Sasaki M, Kouyama M, Tazaki T, Takahashi S, Nakamitsu A World J Gastrointest Pathophysiol. 2022; 13(1):15-33.

PMID: 35116177 PMC: 8788163. DOI: 10.4291/wjgp.v13.i1.15.

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