Salivary Hormones and Quality of Life in Female Postmenopausal Burning Mouth Patients-A Pilot Case-Control Study

Overview

Journal Dent J (Basel)

Specialty Dentistry

Date 2020 Oct 6

PMID 33019769

Citations 3

Authors

Bozana Loncar-Brzak

Valentina Vidranski

Ana Andabak-Rogulj

Danica Vidovic-Juras

Ivana Todoric-Laidlaw

Dragana Gabric

Ivana Skrinjar

Affiliations

Soon will be listed here.

Abstract

The objective of our study was to investigate salivary levels of estradiol, progesterone and dehydroepiandrosterone (DHEA), and quality of life, in female postmenopausal women with burning mouth syndrome. The study included new patients diagnosed with burning mouth syndrome and excluded local and systemic causes. Unstimulated saliva samples were taken in the morning from 9 AM and 11 AM and immediately frozen for hormone analysis. The patients filled out a self-perceived quality of life questionnaire Oral Health Impact Profile-14 and determined the intensity of mucosal symptoms according to the visual-analog scale grading 0 to 10. A total of 40 patients were included. The study group had significantly lower levels of salivary estradiol. No difference was observed in levels of progesterone and DHEA between the groups. The levels of salivary hormones did not exhibit a significant correlation according to the Spearman correlation test with a self-perceived quality of life questionnaire (OHIP-14) in the study group or in the control group. Further research on a larger number of patients is needed to verify these results. This information might help to enable more precise and efficient treatment.

Citing Articles

Salivary hormones in depression: the future in diagnosis and treatment.

Harsanyi S, Kupcova I, Csobonyeiova M, Klein M Ann Gen Psychiatry. 2025; 24(1):9.

PMID: 39962602 PMC: 11834473. DOI: 10.1186/s12991-025-00548-y.

Sex steroid hormones: an overlooked yet fundamental factor in oral homeostasis in humans.

Cornejo Ulloa P, Krom B, Schoonmade L, van der Veen M Front Endocrinol (Lausanne). 2024; 15:1400640.

PMID: 39109076 PMC: 11300310. DOI: 10.3389/fendo.2024.1400640.

Oral mucosal diseases and psychosocial factors: progress in related neurobiological mechanisms.

Zhou H, Lin X J Int Med Res. 2023; 51(12):3000605231218619.

PMID: 38150546 PMC: 10754026. DOI: 10.1177/03000605231218619.

Effects of estradiol on the virulence traits of Porphyromonas gingivalis.

Jayaprakash Demirel K, Neves Guimaraes A, Demirel I Sci Rep. 2022; 12(1):13881.

PMID: 35974048 PMC: 9381592. DOI: 10.1038/s41598-022-17019-z.

References

DE Araujo Lima E, Barbosa N, Santos A, AraujoMouraLemos T, de Souza C, Trevilatto P . Comparative Analysis of Psychological, Hormonal, and Genetic Factors Between Burning Mouth Syndrome and Secondary Oral Burning. Pain Med. 2016; 17(9):1602-11. DOI: 10.1093/pm/pnv087. View

Bale T, Epperson C . Sex differences and stress across the lifespan. Nat Neurosci. 2015; 18(10):1413-20. PMC: 4620712. DOI: 10.1038/nn.4112. View

Craft R . Modulation of pain by estrogens. Pain. 2007; 132 Suppl 1:S3-S12. DOI: 10.1016/j.pain.2007.09.028. View

Strous R, Maayan R, Lapidus R, Stryjer R, Lustig M, Kotler M . Dehydroepiandrosterone augmentation in the management of negative, depressive, and anxiety symptoms in schizophrenia. Arch Gen Psychiatry. 2003; 60(2):133-41. DOI: 10.1001/archpsyc.60.2.133. View

Kibaly C, Meyer L, Patte-Mensah C, Mensah-Nyagan A . Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord. FASEB J. 2007; 22(1):93-104. DOI: 10.1096/fj.07-8930com. View

Villareal D, Holloszy J . Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. JAMA. 2004; 292(18):2243-8. DOI: 10.1001/jama.292.18.2243. View

Amenabar J, Pawlowski J, Hilgert J, Hugo F, Bandeira D, Lhuller F . Anxiety and salivary cortisol levels in patients with burning mouth syndrome: case-control study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 105(4):460-5. DOI: 10.1016/j.tripleo.2007.10.002. View

Nasri C, Teixeira M, Okada M, Formigoni G, Heir G, de Siqueira J . Burning mouth complaints: clinical characteristics of a Brazilian sample. Clinics (Sao Paulo). 2007; 62(5):561-6. DOI: 10.1590/s1807-59322007000500005. View

Bogetto F, Maina G, Ferro G, Carbone M, Gandolfo S . Psychiatric comorbidity in patients with burning mouth syndrome. Psychosom Med. 1998; 60(3):378-85. DOI: 10.1097/00006842-199805000-00028. View

10.

Seeman M . Psychopathology in women and men: focus on female hormones. Am J Psychiatry. 1997; 154(12):1641-7. DOI: 10.1176/ajp.154.12.1641. View

11.

Paller C, Campbell C, Edwards R, Dobs A . Sex-based differences in pain perception and treatment. Pain Med. 2009; 10(2):289-99. PMC: 2745644. DOI: 10.1111/j.1526-4637.2008.00558.x. View

12.

Stein D . Progesterone exerts neuroprotective effects after brain injury. Brain Res Rev. 2007; 57(2):386-97. PMC: 2699575. DOI: 10.1016/j.brainresrev.2007.06.012. View

13.

VAN DER Ploeg H, van der Wal N, Eijkman M, van der Waal I . Psychological aspects of patients with burning mouth syndrome. Oral Surg Oral Med Oral Pathol. 1987; 63(6):664-8. DOI: 10.1016/0030-4220(87)90366-5. View

14.

Scala A, Checchi L, Montevecchi M, Marini I, Giamberardino M . Update on burning mouth syndrome: overview and patient management. Crit Rev Oral Biol Med. 2003; 14(4):275-91. DOI: 10.1177/154411130301400405. View

15.

Zakrzewska J, Buchanan J . Burning mouth syndrome. BMJ Clin Evid. 2016; 2016. PMC: 4704679. View

16.

Grushka M, Epstein J, Gorsky M . Burning mouth syndrome. Am Fam Physician. 2002; 65(4):615-20. View

17.

Andabak Rogulj A, Richter I, Brailo V, Krstevski I, Vucicevic Boras V . CATASTROPHIZING IN PATIENTS WITH BURNING MOUTH SYNDROME. Acta Stomatol Croat. 2016; 48(2):109-15. PMC: 4872800. View

18.

Gao J, Chen L, Zhou J, Peng J . A case-control study on etiological factors involved in patients with burning mouth syndrome. J Oral Pathol Med. 2009; 38(1):24-8. DOI: 10.1111/j.1600-0714.2008.00708.x. View

19.

Casson P, Straughn A, Umstot E, ABRAHAM G, Carson S, Buster J . Delivery of dehydroepiandrosterone to premenopausal women: effects of micronization and nonoral administration. Am J Obstet Gynecol. 1996; 174(2):649-53. DOI: 10.1016/s0002-9378(96)70444-1. View

20.

Grinspan D, Fernandez Blanco G, Allevato M, Stengel F . Burning mouth syndrome. Int J Dermatol. 1995; 34(7):483-7. DOI: 10.1111/j.1365-4362.1995.tb00617.x. View