Cap Z(36/32), a Barbed End Actin-capping Protein, is a Component of the Z-line of Skeletal Muscle

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 1987 Jul 1

PMID 3301868

Citations 56

Authors

J F Casella

S W Craig

D J Maack

A E Brown

Affiliations

Soon will be listed here.

Abstract

Various biological activities have been attributed to actin-capping proteins based on their in vitro effects on actin filaments. However, there is little direct evidence for their in vivo activities. In this paper, we show that Cap Z(36/32), a barbed end, actin-capping protein isolated from muscle (Casella, J. F., D. J. Maack, and S. Lin, 1986, J. Biol. Chem., 261:10915-10921) is localized to the barbed ends of actin filaments by electron microscopy and to the Z-line of chicken skeletal muscle by indirect immunofluorescence and electron microscopy. Since actin filaments associate with the Z-line at their barbed ends, these findings suggest that Cap Z(36/32) may play a role in regulating length, orienting, or attaching actin filaments to Z-discs.

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