Comparison of Peri-implant Soft Tissue and Crestal Bone Status of Dental Implants Placed in Prediabetic, Type 2 Diabetic, and Non-diabetic Individuals: a Retrospective Cohort Study

Overview

Journal Int J Implant Dent

Publisher Springer

Specialty Dentistry

Date 2020 Oct 5

PMID 33015750

Citations 5

Authors

Abdullah Alshahrani

Modhi Al Deeb

Saad Alresayes

Sameer A Mokeem

Nawwaf Al-Hamoudi

Osama Alghamdi

Fahim Vohra

Tariq Abduljabbar

Affiliations

Soon will be listed here.

Abstract

Background: Clinicoradiographic status of narrow-diameter implants (NDIs) among patients with prediabetes and type 2 diabetes mellitus (DM) is scarce. The aim was to address the clinicoradiographic status of NDIs placed prediabetic, type 2 diabetic, and non-diabetic individuals. In this retrospective cohort study, patients having undergone oral rehabilitation with NDI were included. The participants were divided into the following: (a) patients with prediabetes; (b) patients with poorly controlled type 2 DM; (c) patients with well-controlled type 2 DM; and (d) normoglycemic individuals. Demographic data was collected. In all groups, peri-implant plaque index (PI), gingival index (GI), probing depth (PD), and mesiodistal CBL were measured in all groups. Information related to implant dimensions, surface characteristics, insertion torque, implant geometry, duration of NDI in function, and jaw location of NDI was also recorded. Data normality was assessed and group comparisons were performed. A probability value under 0.01 was considered statistically significant.

Results: Eighty-three patients (20 patients had prediabetes, 22 with poorly controlled type 2 DM, 20 with well-controlled type 2 DM, and 20 self-reported non-diabetic individuals) were included. The mean HbA1c levels were significantly higher among patients with prediabetes (P < 0.01) and poorly controlled type 2 DM (P < 0.01) than patients with well-controlled type 2 DM and non-diabetic controls. Peri-implant PI, GI, PD, and mesiodistal CBL levels were significantly higher among patients with pre-diabetes (P < 0.01) and poorly controlled type 2 DM (P < 0.01) than patients with well-controlled type 2 DM and non-diabetic controls. Peri-implant PI, GI, PD, and mesiodistal CBL levels were significantly higher among patients with poorly controlled type 2 DM (P < 0.01) than patients with prediabetes.

Conclusion: Chronic hyperglycemia increases the risk of peri-implant diseases around NDIs.

Citing Articles

Relationship Between Diabetes Mellitus and Periodontal/Peri-Implant Disease: A Contemporaneous Review.

Enteghad S, Shirban F, Nikbakht M, Bagherniya M, Sahebkar A Int Dent J. 2024; 74(3):426-445.

PMID: 38614881 PMC: 11123523. DOI: 10.1016/j.identj.2024.03.010.

Systemic Diseases and Biological Dental Implant Complications: A Narrative Review.

Sbricoli L, Bazzi E, Stellini E, Bacci C Dent J (Basel). 2023; 11(1).

PMID: 36661547 PMC: 9857470. DOI: 10.3390/dj11010010.

Clinical Evaluation of Short Tuberosity Implants among Type 2 Diabetic and Non-Diabetic Patients: A 5 Year Follow-Up.

Tulbah H, Alsahhaf A, AlRumaih H, Vohra F, Abduljabbar T Medicina (Kaunas). 2022; 58(10).

PMID: 36295647 PMC: 9611925. DOI: 10.3390/medicina58101487.

Cortisol Levels in the Peri-implant Sulcular Fluid of Type-2 Diabetic and Non-diabetic Patients with Peri-implantitis.

Ali D, Baskaradoss J, Joseph B Oral Health Prev Dent. 2022; 20:219-226.

PMID: 35481346 PMC: 11641210. DOI: 10.3290/j.ohpd.b2960827.

Peri-implant marginal bone loss and systemic statin use: A retrospective cohort pilot study.

Bahrami-Hessari B, Jansson L Clin Exp Dent Res. 2021; 8(1):20-27.

PMID: 34713988 PMC: 8874104. DOI: 10.1002/cre2.509.

References

Al Amri M, Abduljabbar T, Al-Kheraif A, Romanos G, Javed F . Comparison of clinical and radiographic status around dental implants placed in patients with and without prediabetes: 1-year follow-up outcomes. Clin Oral Implants Res. 2016; 28(2):231-235. DOI: 10.1111/clr.12788. View

Loe H . The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol. 1967; 38(6):Suppl:610-6. DOI: 10.1902/jop.1967.38.6.610. View

Stadler M, Frohlich-Reiterer E, Prager R . [Type 2 Diabetes mellitus-screening and prevention: Update 2016]. Wien Klin Wochenschr. 2016; 128 Suppl 2:S41-4. DOI: 10.1007/s00508-016-0971-3. View

Mokeem S, Alfadda S, Al-Shibani N, Alrabiah M, Al-Hamdan R, Vohra F . Clinical and radiographic peri-implant variables around short dental implants in type 2 diabetic, prediabetic, and non-diabetic patients. Clin Implant Dent Relat Res. 2018; 21(1):60-65. DOI: 10.1111/cid.12691. View

Klein M, Schiegnitz E, Al-Nawas B . Systematic review on success of narrow-diameter dental implants. Int J Oral Maxillofac Implants. 2014; 29 Suppl:43-54. DOI: 10.11607/jomi.2014suppl.g1.3. View

Al-Sowygh Z, Ab Ghani S, Sergis K, Vohra F, Akram Z . Peri-implant conditions and levels of advanced glycation end products among patients with different glycemic control. Clin Implant Dent Relat Res. 2018; 20(3):345-351. DOI: 10.1111/cid.12584. View

Almutairi A, Walid M, Alkhodary M . The effect of osseodensification and different thread designs on the dental implant primary stability. F1000Res. 2019; 7:1898. PMC: 6518436. DOI: 10.12688/f1000research.17292.1. View

Nonaka K, Kajiura Y, Bando M, Sakamoto E, Inagaki Y, Lew J . Advanced glycation end-products increase IL-6 and ICAM-1 expression via RAGE, MAPK and NF-κB pathways in human gingival fibroblasts. J Periodontal Res. 2017; 53(3):334-344. DOI: 10.1111/jre.12518. View

Takeda M, Ojima M, Yoshioka H, Inaba H, Kogo M, Shizukuishi S . Relationship of serum advanced glycation end products with deterioration of periodontitis in type 2 diabetes patients. J Periodontol. 2006; 77(1):15-20. DOI: 10.1902/jop.2006.77.1.15. View

10.

Quintero D, Winger J, Khashaba R, Borke J . Advanced glycation endproducts and rat dental implant osseointegration. J Oral Implantol. 2010; 36(2):97-103. DOI: 10.1563/AAID-JOI-D-09-00032. View

11.

Li G, Han L, Wang Y, Zhao Y, Li Y, Fu J . Evaluation of ADA HbA1c criteria in the diagnosis of pre-diabetes and diabetes in a population of Chinese adolescents and young adults at high risk for diabetes: a cross-sectional study. BMJ Open. 2018; 8(8):e020665. PMC: 6089273. DOI: 10.1136/bmjopen-2017-020665. View

12.

Kilpatrick E, Bloomgarden Z, Zimmet P . International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes: response to the International Expert Committee. Diabetes Care. 2009; 32(12):e159. PMC: 2789675. DOI: 10.2337/dc09-1231. View

13.

Katz J, Yoon T, Mao S, Lamont R, Caudle R . Expression of the receptor of advanced glycation end products in the gingival tissue of smokers with generalized periodontal disease and after nornicotine induction in primary gingival epithelial cells. J Periodontol. 2007; 78(4):736-41. DOI: 10.1902/jop.2007.060381. View

14.

Shilubane N, Cur M . Factors contributing to poor glycaemic control in diabetic patients at Mopani District. Curationis. 2011; 33(3):43-7. DOI: 10.4102/curationis.v33i3.6. View

15.

Shim E, Babu J . Glycated albumin produced in diabetic hyperglycemia promotes monocyte secretion of inflammatory cytokines and bacterial adherence to epithelial cells. J Periodontal Res. 2014; 50(2):197-204. DOI: 10.1111/jre.12194. View

16.

Alrabiah M . Comparison of survival rate and crestal bone loss of narrow diameter dental implants versus regular dental implants: A systematic review and meta-analysis. J Investig Clin Dent. 2018; 10(1):e12367. DOI: 10.1111/jicd.12367. View

17.

Khocht A, Janal M, Harasty L, Chang K . Comparison of direct digital and conventional intraoral radiographs in detecting alveolar bone loss. J Am Dent Assoc. 2003; 134(11):1468-75. DOI: 10.14219/jada.archive.2003.0076. View

18.

Alrabiah M, Alrahlah A, Al-Hamdan R, Al-Aali K, Labban N, Abduljabbar T . Survival of adjacent-dental-implants in prediabetic and systemically healthy subjects at 5-years follow-up. Clin Implant Dent Relat Res. 2019; 21(2):232-237. DOI: 10.1111/cid.12715. View

19.

Javed F, Al-Kheraif A, Al Amri M, Mikami T, Vohra F, Warnakulasuriya S . Periodontal parameters and whole salivary cytokine profiles among habitual gutka chewers and non-chewers. J Periodontol. 2015; 86(5):689-95. DOI: 10.1902/jop.2015.140556. View

20.

Armitage G, Svanberg G, Loe H . Microscopic evaluation of clinical measurements of connective tissue attachment levels. J Clin Periodontol. 1977; 4(3):173-90. DOI: 10.1111/j.1600-051x.1977.tb02271.x. View