Biosurfactants and Anti-inflammatory Activity: A Potential New Approach Towards COVID-19

Overview

Journal Curr Opin Environ Sci Health

Specialty Environmental Health

Date 2020 Oct 5

PMID 33015428

Citations 21

Authors

Mohana Devi Subramaniam

Dhivya Venkatesan

Mahalaxmi Iyer

Sarathbabu Subbarayan

Vivekanandhan Govindasami

Ayan Roy

Arul Narayanasamy

Siva Kamalakannan

Abilash Valsala Gopalakrishnan

Raviminickam Thangarasu

Nachimuthu Senthil Kumar

Balachandar Vellingiri

Affiliations

Soon will be listed here.

Abstract

Coronavirus disease 2019 (COVID-19) has grown to be global public health emergency. The biosurfactants (BSs) are surface-active biomolecules with unique properties and wide applications. Several microbes synthesize secondary metabolites with surface-active properties, which have a wide range of anti-inflammatory and anti-viral roles. The monocytes and neutrophils are activated by bacteria, which subsequently result in high secretion of pro-inflammatory cytokines (TNF-α, IL-6, IL-8, IL-12, Il-18 and IL-1β) and toll-like receptors-2 (TLR-2). Following the inflammatory response, BSs induce the production of cationic proteins, reactive oxygen species (ROS) and lysozyme, and thus can be used for therapeutic purposes. This article provides recent advances in the anti-inflammatory and antiviral activities of BSs and discusses the potential use of these compounds against COVID-19, highlighting the need for in-vitro and in-vivo approaches to confirm this hypothesis. This suggestion is necessary because there are still no studies that have focused on the use of BSs against COVID-19.

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References

Akhmerov A, Marban E . COVID-19 and the Heart. Circ Res. 2020; 126(10):1443-1455. DOI: 10.1161/CIRCRESAHA.120.317055. View

Gaur V, Regar R, Dhiman N, Gautam K, Srivastava J, Patnaik S . Biosynthesis and characterization of sophorolipid biosurfactant by Candida spp.: Application as food emulsifier and antibacterial agent. Bioresour Technol. 2019; 285:121314. DOI: 10.1016/j.biortech.2019.121314. View

Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A . Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020; 323(16):1574-1581. PMC: 7136855. DOI: 10.1001/jama.2020.5394. View

Chereshnev V, Gein S, Baeva T, Galkina T, Kuyukina M, Ivshina I . Modulation of cytokine secretion and oxidative metabolism of innate immune effectors by Rhodococcus biosurfactant. Bull Exp Biol Med. 2010; 149(6):734-8. DOI: 10.1007/s10517-010-1039-4. View

Haque F, Sajid M, Cameotra S, Battacharyya M . Anti-biofilm activity of a sophorolipid-amphotericin B niosomal formulation against Candida albicans. Biofouling. 2017; 33(9):768-779. DOI: 10.1080/08927014.2017.1363191. View

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y . Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395(10223):497-506. PMC: 7159299. DOI: 10.1016/S0140-6736(20)30183-5. View

Morita Y, Tadokoro S, Sasai M, Kitamoto D, Hirashima N . Biosurfactant mannosyl-erythritol lipid inhibits secretion of inflammatory mediators from RBL-2H3 cells. Biochim Biophys Acta. 2011; 1810(12):1302-8. DOI: 10.1016/j.bbagen.2011.07.002. View

Iyer M, Jayaramayya K, Subramaniam M, Lee S, Abdal Dayem A, Cho S . COVID-19: an update on diagnostic and therapeutic approaches. BMB Rep. 2020; 53(4):191-205. PMC: 7196187. View

Bluth M, Kandil E, Mueller C, Shah V, Lin Y, Zhang H . Sophorolipids block lethal effects of septic shock in rats in a cecal ligation and puncture model of experimental sepsis. Crit Care Med. 2005; 34(1):188-95. DOI: 10.1097/01.ccm.0000196212.56885.50. View

10.

Chan J, Yuan S, Kok K, To K, Chu H, Yang J . A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020; 395(10223):514-523. PMC: 7159286. DOI: 10.1016/S0140-6736(20)30154-9. View

11.

Wang W, Liu X, Wu S, Chen S, Li Y, Nong L . Definition and Risks of Cytokine Release Syndrome in 11 Critically Ill COVID-19 Patients With Pneumonia: Analysis of Disease Characteristics. J Infect Dis. 2020; 222(9):1444-1451. PMC: 7337810. DOI: 10.1093/infdis/jiaa387. View

12.

Kracht M, Rokos H, Ozel M, Kowall M, Pauli G, Vater J . Antiviral and hemolytic activities of surfactin isoforms and their methyl ester derivatives. J Antibiot (Tokyo). 1999; 52(7):613-9. DOI: 10.7164/antibiotics.52.613. View

13.

Bakur A, Niu Y, Kuang H, Chen Q . Synthesis of gold nanoparticles derived from mannosylerythritol lipid and evaluation of their bioactivities. AMB Express. 2019; 9(1):62. PMC: 6505018. DOI: 10.1186/s13568-019-0785-6. View

14.

Borsanyiova M, Patil A, Mukherji R, Prabhune A, Bopegamage S . Biological activity of sophorolipids and their possible use as antiviral agents. Folia Microbiol (Praha). 2015; 61(1):85-9. DOI: 10.1007/s12223-015-0413-z. View

15.

Venugopal A, Ganesan H, Sudalaimuthu Raja S, Govindasamy V, Arunachalam M, Narayanasamy A . Novel wastewater surveillance strategy for early detection of coronavirus disease 2019 hotspots. Curr Opin Environ Sci Health. 2020; 17:8-13. PMC: 7245214. DOI: 10.1016/j.coesh.2020.05.003. View

16.

Solaiman D, Ashby R, Uknalis J . Characterization of growth inhibition of oral bacteria by sophorolipid using a microplate-format assay. J Microbiol Methods. 2017; 136:21-29. DOI: 10.1016/j.mimet.2017.02.012. View

17.

Naughton P, Marchant R, Naughton V, Banat I . Microbial biosurfactants: current trends and applications in agricultural and biomedical industries. J Appl Microbiol. 2019; 127(1):12-28. DOI: 10.1111/jam.14243. View

18.

Sajid M, Khan M, Cameotra S, Safar Al-Thubiani A . Biosurfactants: Potential applications as immunomodulator drugs. Immunol Lett. 2020; 223:71-77. DOI: 10.1016/j.imlet.2020.04.003. View

19.

Singh P, Cameotra S . Potential applications of microbial surfactants in biomedical sciences. Trends Biotechnol. 2004; 22(3):142-6. DOI: 10.1016/j.tibtech.2004.01.010. View

20.

Baeva T, Gein S, Kuyukina M, Ivshina I, Kochina O, Chereshnev V . Effect of glycolipid Rhodococcus biosurfactant on secretory activity of neutrophils in vitro. Bull Exp Biol Med. 2014; 157(2):238-42. DOI: 10.1007/s10517-014-2534-9. View