SerpinA3N Deficiency Deteriorates Impairments of Learning and Memory in Mice Following Hippocampal Stab Injury

Overview

Journal Cell Death Discov

Date 2020 Oct 5

PMID 33014432

Citations 19

Authors

Zhi-Meng Wang

Cong Liu

Ying-Ying Wang

Yu-Sen Deng

Xuan-Cheng He

Hong-Zhen Du

Chang-Mei Liu

Zhao-Qian Teng

Affiliations

Soon will be listed here.

Abstract

Traumatic brain injury is a global leading cause of disability and death, which puts patients at high risk for developing dementia. Early intervention is believed as the key to minimize the development of brain damages that could aggravate the symptoms. Here, we report that the serine protease inhibitor SerpinA3N is upregulated in hippocampal neurons in the early stage of hippocampal stab injury (HSI), while its deficiency causes a greater degree of neuronal apoptosis and severer impairments of spatial learning and memory in mice after HSI. We further show that MMP2 is a key substrate of SerpinA3N, and MMP2 specific inhibitor (ARP100) can protect against neuronal apoptosis and cognitive dysfunction in mice after HSI. These findings demonstrate a critical role for SerpinA3N in neuroprotection, suggesting that SerpinA3N and MMP2 inhibitors might be a novel therapeutic agents for neurotrauma.

Citing Articles

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