Associations of Triglyceride-Glucose Index and Its Derivatives with Hyperuricemia Risk: A Cohort Study in Chinese General Population

Overview

Journal Int J Endocrinol

Publisher Wiley

Specialty Endocrinology

Date 2020 Oct 5

PMID 33014043

Citations 19

Authors

Qing Gu

Xue Hu

Jian Meng

Jun Ge

Sui Jun Wang

Xing Zhen Liu

Affiliations

Soon will be listed here.

Abstract

Background: Identification and intervention of insulin resistance may be beneficial to the prevention of hyperuricemia (HUA) and its related diseases. Thus, we conducted this longitudinal study to examine the relation of triglyceride-glucose index (TyG), a simple noninsulin-based IR assessment tool, and its derivatives with the risk of HUA.

Methods: A total of 42,387 adults who received routine health screening and were free of HUA were included for the longitudinal analyses. TyG, body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WtHR) were calculated through anthropometric and biochemical indicators. Associations of TyG, TyG-BMI, TyG-WC, and TyG-WHtR with HUA risk were estimated using Cox regression analyses.

Results: The incident cases of HUA occurred in 4,230 subjects during the 138,163 person-years of observation, and the crude incidence rate of HUA was 30.6 per 1000 person-years. After multivariate adjustment, we observed an increased risk for incident HUA for the upper TyG and its derivatives' tercile. The HRs of TyG were greater than that of its components in both sexes. Compared with TyG, TyG-related parameters only had higher HRs in women but not in men.

Conclusions: TyG and its integration with obesity indicators have the potential to help risk stratification and prevention of HUA, especially among women.

Citing Articles

Association Between TyG-BMI Index and Hyperuricemia in Adult Women.

Mutailipu K, Guo J, Yin J, Wang Y, Lu L, Jia X Endocrinol Diabetes Metab. 2025; 8(2):e70028.

PMID: 39901609 PMC: 11791015. DOI: 10.1002/edm2.70028.

Sex-Based Differences in the Associations Between Obesity- and Lipid-Related Indexes and Hyperuricemia Risk in Patients with Obesity.

Mutailipu K, Du L, Guo J, Liu S, Chen Y, Lu L Diabetes Metab Syndr Obes. 2024; 17:4721-4733.

PMID: 39678227 PMC: 11639956. DOI: 10.2147/DMSO.S483638.

Triglyceride-glucose index and its additive interaction with polygenic risk score on hyperuricemia in middle age and older adults: findings from the DLCC and BHMC study.

He H, Cheng Q, Chen S, Li Q, Zhang J, Shan G Ann Med. 2024; 56(1):2434186.

PMID: 39607832 PMC: 11610346. DOI: 10.1080/07853890.2024.2434186.

Triglyceride Glucose Body Mass Index as 3 Year Prognostic Indicator for Major Adverse Cardiovascular and Cerebrovascular Events in Patients with Acute Myocardial Infarction After PCI: A Prospective Cohort Study.

Yang Y, Wang Y, Pei X Clin Interv Aging. 2024; 19:1341-1350.

PMID: 39050521 PMC: 11268843. DOI: 10.2147/CIA.S473481.

Association of triglyceride glucose index and triglyceride glucose-body mass index with sudden cardiac arrest in the general population.

Zhang S, Liu W, Xu B, Wang S, Du Z, Cheng W Cardiovasc Diabetol. 2024; 23(1):173.

PMID: 38762473 PMC: 11102616. DOI: 10.1186/s12933-024-02275-2.

References

Zeng Z, Liu S, Xu H, Xu X, Liu X, Zhao X . Association of triglyceride glucose index and its combination of obesity indices with prehypertension in lean individuals: A cross-sectional study of Chinese adults. J Clin Hypertens (Greenwich). 2020; 22(6):1025-1032. PMC: 8029919. DOI: 10.1111/jch.13878. View

Hyndman D, Liu S, Miner J . Urate Handling in the Human Body. Curr Rheumatol Rep. 2016; 18(6):34. PMC: 4841844. DOI: 10.1007/s11926-016-0587-7. View

Kanbay M, Jensen T, Solak Y, Le M, Roncal-Jimenez C, Rivard C . Uric acid in metabolic syndrome: From an innocent bystander to a central player. Eur J Intern Med. 2015; 29:3-8. PMC: 4826346. DOI: 10.1016/j.ejim.2015.11.026. View

Cao J, Wang C, Zhang G, Ji X, Liu Y, Sun X . Incidence and Simple Prediction Model of Hyperuricemia for Urban Han Chinese Adults: A Prospective Cohort Study. Int J Environ Res Public Health. 2017; 14(1). PMC: 5295318. DOI: 10.3390/ijerph14010067. View

Stiburkova B, Pavelcova K, Pavlikova M, Jesina P, Pavelka K . The impact of dysfunctional variants of ABCG2 on hyperuricemia and gout in pediatric-onset patients. Arthritis Res Ther. 2019; 21(1):77. PMC: 6425717. DOI: 10.1186/s13075-019-1860-8. View

Browning L, Hsieh S, Ashwell M . A systematic review of waist-to-height ratio as a screening tool for the prediction of cardiovascular disease and diabetes: 0·5 could be a suitable global boundary value. Nutr Res Rev. 2010; 23(2):247-69. DOI: 10.1017/S0954422410000144. View

Manley S, Stratton I, Clark P, Luzio S . Comparison of 11 human insulin assays: implications for clinical investigation and research. Clin Chem. 2007; 53(5):922-32. DOI: 10.1373/clinchem.2006.077784. View

Nakagawa T, Cirillo P, Sato W, Gersch M, Sautin Y, Roncal C . The conundrum of hyperuricemia, metabolic syndrome, and renal disease. Intern Emerg Med. 2008; 3(4):313-8. PMC: 2895906. DOI: 10.1007/s11739-008-0141-3. View

Bjornstad P, Eckel R . Pathogenesis of Lipid Disorders in Insulin Resistance: a Brief Review. Curr Diab Rep. 2018; 18(12):127. PMC: 6428207. DOI: 10.1007/s11892-018-1101-6. View

10.

Testa A, Prudente S, Leonardis D, Spoto B, Sanguedolce M, Parlongo R . A genetic marker of hyperuricemia predicts cardiovascular events in a meta-analysis of three cohort studies in high risk patients. Nutr Metab Cardiovasc Dis. 2015; 25(12):1087-94. DOI: 10.1016/j.numecd.2015.08.004. View

11.

Mandal A, Mount D . The molecular physiology of uric acid homeostasis. Annu Rev Physiol. 2014; 77:323-45. DOI: 10.1146/annurev-physiol-021113-170343. View

12.

Wan H, Zhang K, Wang Y, Chen Y, Zhang W, Xia F . The Associations Between Gonadal Hormones and Serum Uric Acid Levels in Men and Postmenopausal Women With Diabetes. Front Endocrinol (Lausanne). 2020; 11:55. PMC: 7044188. DOI: 10.3389/fendo.2020.00055. View

13.

Liu X, Wu Q, Chen Z, Yan G, Lu Y, Dai H . Elevated triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio increased risk of hyperuricemia: a 4-year cohort study in China. Endocrine. 2020; 68(1):71-80. DOI: 10.1007/s12020-019-02176-5. View

14.

Whitehead T, Jungner I, Robinson D, Kolar W, Pearl A, Hale A . Serum urate, serum glucose and diabetes. Ann Clin Biochem. 1992; 29 ( Pt 2):159-61. DOI: 10.1177/000456329202900206. View

15.

Groop L, Bonadonna R, DelPrato S, Ratheiser K, Zyck K, Ferrannini E . Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance. J Clin Invest. 1989; 84(1):205-13. PMC: 303971. DOI: 10.1172/JCI114142. View

16.

Feig D, Kang D, Johnson R . Uric acid and cardiovascular risk. N Engl J Med. 2008; 359(17):1811-21. PMC: 2684330. DOI: 10.1056/NEJMra0800885. View

17.

Wang T, Lu J, Shi L, Chen G, Xu M, Xu Y . Association of insulin resistance and β-cell dysfunction with incident diabetes among adults in China: a nationwide, population-based, prospective cohort study. Lancet Diabetes Endocrinol. 2019; 8(2):115-124. DOI: 10.1016/S2213-8587(19)30425-5. View

18.

Nakayama A, Matsuo H, Nakaoka H, Nakamura T, Nakashima H, Takada Y . Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors. Sci Rep. 2014; 4:5227. PMC: 5381477. DOI: 10.1038/srep05227. View

19.

Bala C, Gheorghe-Fronea O, Pop D, Pop C, Caloian B, Comsa H . The Association Between Six Surrogate Insulin Resistance Indexes and Hypertension: A Population-Based Study. Metab Syndr Relat Disord. 2019; 17(6):328-333. DOI: 10.1089/met.2018.0122. View

20.

Simental-Mendia L, Rodriguez-Moran M, Guerrero-Romero F . The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab Syndr Relat Disord. 2008; 6(4):299-304. DOI: 10.1089/met.2008.0034. View