Mouse Genetic Reference Populations: Cellular Platforms for Integrative Systems Genetics

Overview

Journal Trends Genet

Specialty Genetics

Date 2020 Oct 4

PMID 33010949

Citations 14

Authors

Emily Swanzey

Callan OConnor

Laura G Reinholdt

Affiliations

Soon will be listed here.

Abstract

Interrogation of disease-relevant cellular and molecular traits exhibited by genetically diverse cell populations enables in vitro systems genetics approaches for uncovering the basic properties of cellular function and identity. Primary cells, stem cells, and organoids derived from genetically diverse mouse strains, such as Collaborative Cross and Diversity Outbred populations, offer the opportunity for parallel in vitro/in vivo screening. These panels provide genetic resolution for variant discovery and functional characterization, as well as disease modeling and in vivo validation capabilities. Here we review mouse cellular systems genetics approaches for characterizing the influence of genetic variation on signaling networks and phenotypic diversity, and we discuss approaches for data integration and cross-species validation.

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