Galvanic Replacement Reaction for in Situ Fabrication of Litchi-shaped Heterogeneous Liquid Metal-Au Nano-composite for Radio-photothermal Cancer Therapy

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2020 Oct 2

PMID 33005825

Citations 4

Authors

Zhenhu Guo

Jingsong Lu

Dan Wang

Wensheng Xie

Yongjie Chi

Jianzhong Xu

Nonaka Takuya

Junxin Zhang

Wanling Xu

Fei Gao

Hong Wu

Lingyun Zhao

Affiliations

Soon will be listed here.

Abstract

With tremendous research advances in biomedical application, liquid metals (LM) also offer fantastic chemistry for synthesis of novel nano-composites. Herein, as a pioneering trial, litchi-shaped heterogeneous eutectic gallium indium-Au nanoparticles (EGaIn-Au NPs), served as effective radiosensitizer and photothermal agent for radio-photothermal cancer therapy, have been successfully prepared using in situ interfacial galvanic replacement reaction. The enhanced photothermal conversion efficiency and boosted radio-sensitization effect could be achieved with the reduction of Au nanodots onto the eutectic gallium indium (EGaIn) NPs surface. Most importantly, the growth of tumor could be effectively inhibited under the combined radio-photothermal therapy mediated by EGaIn-Au NPs. Inspired by this approach, in situ interfacial galvanic replacement reaction may open a novel strategy to fabricate LM-based nano-composite with advanced multi-functionalities.

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References

Martin A, Kiarie W, Chang B, Thuo M . Chameleon Metals: Autonomous Nano-Texturing and Composition Inversion on Liquid Metals Surfaces. Angew Chem Int Ed Engl. 2019; 59(1):352-357. DOI: 10.1002/anie.201912639. View

Pan C, Markvicka E, Malakooti M, Yan J, Hu L, Matyjaszewski K . A Liquid-Metal-Elastomer Nanocomposite for Stretchable Dielectric Materials. Adv Mater. 2019; 31(23):e1900663. DOI: 10.1002/adma.201900663. View

Liang S, Rao W, Song K, Liu J . Fluorescent Liquid Metal As a Transformable Biomimetic Chameleon. ACS Appl Mater Interfaces. 2017; 10(2):1589-1596. DOI: 10.1021/acsami.7b17233. View

Kulkarni S, Pandey A, Mutalik S . Liquid metal based theranostic nanoplatforms: Application in cancer therapy, imaging and biosensing. Nanomedicine. 2020; 26:102175. DOI: 10.1016/j.nano.2020.102175. View

Chen Q, Chen J, Yang Z, Xu J, Xu L, Liang C . Nanoparticle-Enhanced Radiotherapy to Trigger Robust Cancer Immunotherapy. Adv Mater. 2019; 31(10):e1802228. DOI: 10.1002/adma.201802228. View

Tang S, Sivan V, Khoshmanesh K, OMullane A, Tang X, Gol B . Electrochemically induced actuation of liquid metal marbles. Nanoscale. 2013; 5(13):5949-57. DOI: 10.1039/c3nr00185g. View

Roper D, Ahn W, Hoepfner M . Microscale Heat Transfer Transduced by Surface Plasmon Resonant Gold Nanoparticles. J Phys Chem C Nanomater Interfaces. 2008; 111(9):3636-3641. PMC: 2583113. DOI: 10.1021/jp064341w. View

Wang D, Xie W, Gao Q, Yan H, Zhang J, Lu J . Non-Magnetic Injectable Implant for Magnetic Field-Driven Thermochemotherapy and Dual Stimuli-Responsive Drug Delivery: Transformable Liquid Metal Hybrid Platform for Cancer Theranostics. Small. 2019; 15(16):e1900511. DOI: 10.1002/smll.201900511. View

Lin Y, Liu Y, Genzer J, Dickey M . Shape-transformable liquid metal nanoparticles in aqueous solution. Chem Sci. 2017; 8(5):3832-3837. PMC: 5436598. DOI: 10.1039/c7sc00057j. View

10.

Chechetka S, Yu Y, Zhen X, Pramanik M, Pu K, Miyako E . Light-driven liquid metal nanotransformers for biomedical theranostics. Nat Commun. 2017; 8:15432. PMC: 5460022. DOI: 10.1038/ncomms15432. View

11.

Lu Y, Lin Y, Chen Z, Hu Q, Liu Y, Yu S . Enhanced Endosomal Escape by Light-Fueled Liquid-Metal Transformer. Nano Lett. 2017; 17(4):2138-2145. DOI: 10.1021/acs.nanolett.6b04346. View

12.

Daeneke T, Khoshmanesh K, Mahmood N, de Castro I, Esrafilzadeh D, Barrow S . Liquid metals: fundamentals and applications in chemistry. Chem Soc Rev. 2018; 47(11):4073-4111. DOI: 10.1039/c7cs00043j. View

13.

Kim D, Hwang J, Choi Y, Kwon Y, Jang J, Yoon S . Effective Delivery of Anti-Cancer Drug Molecules with Shape Transforming Liquid Metal Particles. Cancers (Basel). 2019; 11(11). PMC: 6896188. DOI: 10.3390/cancers11111666. View

14.

Wang Q, Yu Y, Pan K, Liu J . Liquid metal angiography for mega contrast X-ray visualization of vascular network in reconstructing in-vitro organ anatomy. IEEE Trans Biomed Eng. 2014; 61(7):2161-6. DOI: 10.1109/TBME.2014.2317554. View

15.

Liu Y, Bhattarai P, Dai Z, Chen X . Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer. Chem Soc Rev. 2018; 48(7):2053-2108. PMC: 6437026. DOI: 10.1039/c8cs00618k. View

16.

Yamaguchi A, Mashima Y, Iyoda T . Reversible Size Control of Liquid-Metal Nanoparticles under Ultrasonication. Angew Chem Int Ed Engl. 2015; 54(43):12809-13. DOI: 10.1002/anie.201506469. View

17.

Cui Y, Liang F, Ji C, Xu S, Wang H, Lin Z . Discoloration Effect and One-Step Synthesis of Hydrogen Tungsten and Molybdenum Bronze (H MO) using Liquid Metal at Room Temperature. ACS Omega. 2019; 4(4):7428-7435. PMC: 6648284. DOI: 10.1021/acsomega.9b00840. View

18.

Wu Q, Xia N, Long D, Tan L, Rao W, Yu J . Dual-Functional Supernanoparticles with Microwave Dynamic Therapy and Microwave Thermal Therapy. Nano Lett. 2019; 19(8):5277-5286. DOI: 10.1021/acs.nanolett.9b01735. View

19.

Yan J, Lu Y, Chen G, Yang M, Gu Z . Advances in liquid metals for biomedical applications. Chem Soc Rev. 2018; 47(8):2518-2533. DOI: 10.1039/C7CS00309A. View

20.

Yi L, Jin C, Wang L, Liu J . Liquid-solid phase transition alloy as reversible and rapid molding bone cement. Biomaterials. 2014; 35(37):9789-9801. DOI: 10.1016/j.biomaterials.2014.08.048. View