Intestinal Can Cause Liver Injury Through the Occurrence of Inflammation and Damage to Hepatocytes

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2020 Oct 2

PMID 33005688

Citations 2

Authors

Soomin Lee

Heeyoung Lee

Sejeong Kim

Jeeyeon Lee

Jimyeong Ha

Yukyung Choi

Hyemin Oh

Yujin Kim

Yewon Lee

Kyoung-Hee Choi

Yohan Yoon

Affiliations

Soon will be listed here.

Abstract

This study investigated if intestinal (CD) causes liver injury. Four-week-old male C3H/HeN mice were treated with phosphate-buffered solution (control), CD, diethylnitrosamine (DEN) to induce liver injury with PBS (DEN+PBS), and DEN with CD (DEN+CD) for nine weeks. After sacrifice, livers and mesenteric lymph nodes (MLNs) were removed and bacterial translocation, transcriptomes, and proteins were analysed. CD was found in 20% of MLNs from the control and DEN+PBS groups, in 30% of MLNs from the CD group, and in 75% of MLNs from the DEN+CD groups, which had injured livers. Also, CD was detected in 50% of the livers in the DEN+CD group with CD-positive MLNs. Elevated , , , , , , , and expressions were observed in the CD and DEN+CD groups as compared to the control and DEN+PBS groups. Protein levels of IL-6 and HMGB1 were higher in the CD and DEN+CD groups than in the control and DEN+PBS groups. These results indicate that intestinal CD can initiate and aggravate liver injury, and the mechanism of pathogenesis for liver injury should be investigated in further studies.

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