TGIF1-Twist1 Axis in Pancreatic Ductal Adenocarcinoma

Overview

Journal Comput Struct Biotechnol J

Specialty Biotechnology

Date 2020 Oct 2

PMID 33005315

Citations 9

Authors

Mohammed S Razzaque

Azeddine Atfi

Affiliations

Soon will be listed here.

Abstract

TG-interacting factor 1 (TGIF1) exerts inhibitory effects on transforming growth factor-beta (TGF-β) signaling by suppressing Smad signaling pathway at multiple levels. TGIF1 activity is important for normal embryogenesis and organogenesis, yet its dysregulation can culminate in tumorigenesis. For instance, increased expression of TGIF1 correlates with poor prognosis in triple-negative breast cancer patients, and enforced expression of TGIF1 facilitates Wnt-driven mammary tumorigenesis, suggesting that TGIF1 might function as an oncoprotein. Quite surprisingly, TGIF1 has recently been shown to function as a tumor suppressor in pancreatic ductal adenocarcinoma (PDAC), possibly owing to its ability to antagonize the pro-malignant transcription factor Twist1. In this article, we will briefly elaborate on the biological and clinical significance of the unique tumor-suppressive function of TGIF1 and its functional interaction with Twist1 in the context of PDAC pathogenesis and progression.

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References

Mani S, Guo W, Liao M, Eaton E, Ayyanan A, Zhou A . The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008; 133(4):704-15. PMC: 2728032. DOI: 10.1016/j.cell.2008.03.027. View

Wendt M, Tian M, Schiemann W . Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression. Cell Tissue Res. 2011; 347(1):85-101. PMC: 3723118. DOI: 10.1007/s00441-011-1199-1. View

Friedman E, Gold L, Klimstra D, Zeng Z, Winawer S, Cohen A . High levels of transforming growth factor beta 1 correlate with disease progression in human colon cancer. Cancer Epidemiol Biomarkers Prev. 1995; 4(5):549-54. View

Thiery J, Acloque H, Huang R, Nieto M . Epithelial-mesenchymal transitions in development and disease. Cell. 2009; 139(5):871-90. DOI: 10.1016/j.cell.2009.11.007. View

Wang S, Coljee V, Pignolo R, Rotenberg M, Cristofalo V, Sierra F . Cloning of the human twist gene: its expression is retained in adult mesodermally-derived tissues. Gene. 1997; 187(1):83-92. View

Hamid R, Patterson J, Brandt S . Genomic structure, alternative splicing and expression of TG-interacting factor, in human myeloid leukemia blasts and cell lines. Biochim Biophys Acta. 2008; 1779(5):347-55. DOI: 10.1016/j.bbagrm.2008.04.003. View

Tian M, Neil J, Schiemann W . Transforming growth factor-β and the hallmarks of cancer. Cell Signal. 2010; 23(6):951-62. PMC: 3076078. DOI: 10.1016/j.cellsig.2010.10.015. View

Quante A, Ming C, Rottmann M, Engel J, Boeck S, Heinemann V . Projections of cancer incidence and cancer-related deaths in Germany by 2020 and 2030. Cancer Med. 2016; 5(9):2649-56. PMC: 5055190. DOI: 10.1002/cam4.767. View

Zhang M, Ferrigno O, Wang Z, Ohnishi M, Prunier C, Levy L . TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis. Cancer Cell. 2015; 27(4):547-60. PMC: 4398914. DOI: 10.1016/j.ccell.2015.03.002. View

10.

Qian B, Pollard J . Macrophage diversity enhances tumor progression and metastasis. Cell. 2010; 141(1):39-51. PMC: 4994190. DOI: 10.1016/j.cell.2010.03.014. View

11.

Locasale J, Cantley L . Metabolic flux and the regulation of mammalian cell growth. Cell Metab. 2011; 14(4):443-51. PMC: 3196640. DOI: 10.1016/j.cmet.2011.07.014. View

12.

Goumans M, Liu Z, Ten Dijke P . TGF-beta signaling in vascular biology and dysfunction. Cell Res. 2008; 19(1):116-27. DOI: 10.1038/cr.2008.326. View

13.

Wang X, Yin G, Zhang Z, Rong Z, Wang Z, Du D . TWIST1 transcriptionally regulates glycolytic genes to promote the Warburg metabolism in pancreatic cancer. Exp Cell Res. 2019; 386(1):111713. DOI: 10.1016/j.yexcr.2019.111713. View

14.

Kuang C, Xiao Y, Yang L, Chen Q, Wang Z, Conway S . Intragenic deletion of Tgif causes defectsin brain development. Hum Mol Genet. 2006; 15(24):3508-19. DOI: 10.1093/hmg/ddl427. View

15.

Drabsch Y, Ten Dijke P . TGF-β signalling and its role in cancer progression and metastasis. Cancer Metastasis Rev. 2012; 31(3-4):553-68. DOI: 10.1007/s10555-012-9375-7. View

16.

Principe D, Doll J, Bauer J, Jung B, Munshi H, Bartholin L . TGF-β: duality of function between tumor prevention and carcinogenesis. J Natl Cancer Inst. 2014; 106(2):djt369. PMC: 3952197. DOI: 10.1093/jnci/djt369. View

17.

Razzaque M, Atfi A . Regulatory Role of the Transcription Factor Twist1 in Cancer-Associated Muscle Cachexia. Front Physiol. 2020; 11:662. PMC: 7324683. DOI: 10.3389/fphys.2020.00662. View

18.

El Ghouzzi V, Le Merrer M, Perrin-Schmitt F, Lajeunie E, Benit P, Renier D . Mutations of the TWIST gene in the Saethre-Chotzen syndrome. Nat Genet. 1997; 15(1):42-6. DOI: 10.1038/ng0197-42. View

19.

Lee K, Bar-Sagi D . Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. Cancer Cell. 2010; 18(5):448-58. PMC: 3397918. DOI: 10.1016/j.ccr.2010.10.020. View

20.

Tuveson D, Shaw A, Willis N, Silver D, Jackson E, Chang S . Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell. 2004; 5(4):375-87. DOI: 10.1016/s1535-6108(04)00085-6. View