Erythropoietin in Haemangioblastoma: Immunohistochemical and Electron Microscopy Studies

Overview

Journal Acta Neurochir (Wien)

Specialty Neurosurgery

Date 1987 Jan 1

PMID 3300179

Citations 4

Authors

H Kamitani

H Masuzawa

J Sato

I Kanazawa

Affiliations

Soon will be listed here.

Abstract

Immunohistochemical studies for erythropoietin were carried out in six capillary haemangioblastomas, three of which were also studied by electron microscopy. The immunohistochemical studies showed that positively stained cells were scattered in the vicinity of capillaries, and that neither endothelial cells nor stromal cells were stained. In their morphology and distribution, the positively stained cells were identical to mast cells as observed by electron microscopy. In one case, erythropoietin was demonstrated in the cyst fluid of the tumour. These findings suggest that mast cells with abundant secreting granules in haemangioblastomas are capable of producing erythropoietin.

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