Multidimensional Prognostic Index (MPI) in Elderly Patients with Acute Myocardial Infarction

Overview

Journal Aging Clin Exp Res

Publisher Springer

Specialty Geriatrics

Date 2020 Oct 1

PMID 33001403

Citations 11

Authors

Valeria Cammalleri

Michela Bonanni

Francesca Maria Bueti

Andrea Matteucci

Lisa Cammalleri

Giuseppe Stifano

Saverio Muscoli

Francesco Romeo

Affiliations

Soon will be listed here.

Abstract

Background: Management of elderly patients with acute myocardial infarction (AMI) is challenging due to lack of knowledge about the link between fragility, outcomes and interventional procedures.

Aims: The aim of this study was to establish the prognostic role of the Multidimensional Prognostic Index (MPI) in elderly with AMI.

Methods: A total of 241 patients ≥ 65 years old with AMI were continuously enrolled in this prospective study and divided into three groups according to the MPI score. The primary endpoint was 30-day mortality. Secondary endpoints were 6-month mortality and rate of adverse events.

Results: In-hospital overall mortality rate was higher in MPI-3 (p = 0.009). Patients of MPI-3 had a significantly higher mortality rate regarding the primary endpoint with 30-day survival of 78.9%, compared to 97.4% and 97.2%, in MPI-1, MPI-2 (p < 0.001), respectively. The survival rate progressively decreased in the three MPI classes of risk with a 6-month survival of 96.5%, 96.3%, 73.7% in groups MPI-1, MPI-2, and MPI-3 (p < 0.001). Longer length of in-hospital stay was observed in MPI-3 group. In-hospital complications were more frequent in higher MPI score.

Discussion: Our findings are in agreement with the results of other studies that evaluated the risk of in-hospital complications and mortality in older patients. In our "real-world" population of elderly hospitalized for AMI we observed poorer outcomes in patients belonged to higher MPI groups.

Conclusions: In the setting of AMI, MPI may be very useful in the daily clinical practice to manage older patients and predict the risk of in-hospital and follow-up complications.

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Orthogeriatric Assessment of the Elderly Patient with Fragility Hip Fracture: Preliminary Results of a Prospective Study.

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Salis F, Cossu E, Mandas A J Endocrinol Invest. 2023; 47(1):191-200.

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Fusario D, Neri A, Carbone L, Resca L, Marano L, Gassi G World J Surg. 2023; 47(7):1713-1720.

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