Recent Progress in the Use of Mitochondrial Membrane Permeability Transition Pore in Mitochondrial Dysfunction-related Disease Therapies

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 2020 Oct 1

PMID 33000352

Citations 17

Authors

Yuting Cui

Mingyue Pan

Jing Ma

Xinhua Song

Weiling Cao

Peng Zhang

Affiliations

Soon will be listed here.

Abstract

Mitochondria have various cellular functions, including ATP synthesis, calcium homeostasis, cell senescence, and death. Mitochondrial dysfunction has been identified in a variety of disorders correlated with human health. Among the many underlying mechanisms of mitochondrial dysfunction, the opening up of the mitochondrial permeability transition pore (mPTP) is one that has drawn increasing interest in recent years. It plays an important role in apoptosis and necrosis; however, the molecular structure and function of the mPTP have still not been fully elucidated. In recent years, the abnormal opening up of the mPTP has been implicated in the development and pathogenesis of diverse diseases including ischemia/reperfusion injury (IRI), neurodegenerative disorders, tumors, and chronic obstructive pulmonary disease (COPD). This review provides a systematic introduction to the possible molecular makeup of the mPTP and summarizes the mitochondrial dysfunction-correlated diseases and highlights possible underlying mechanisms. Since the mPTP is an important target in mitochondrial dysfunction, this review also summarizes potential treatments, which may be used to inhibit pore opening up via the molecules composing mPTP complexes, thus suppressing the progression of mitochondrial dysfunction-related diseases.

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