Expression of Eosinophils, RANTES and IL-25 in the First Phase of Hymenoptera Venom Immunotherapy

Overview

Journal Postepy Dermatol Alergol

Publisher Termedia

Specialty Allergy & Immunology

Date 2020 Sep 30

PMID 32994784

Citations 2

Authors

Krzysztof Palgan

Magdalena Zbikowska-Gotz

Zbigniew Bartuzi

Affiliations

Soon will be listed here.

Abstract

Introduction: Venom immunotherapy (VIT) can protect against severe anaphylactic reactions (SR) in 80-100% of subjects allergic to Hymenoptera venom. The mechanisms of induction of immunological tolerance produced by VIT are still little known. It has been shown that VIT modulates Treg activity, Th2 or Th1 cells or both, increases production of IL-10, decreases secretion of IL-13, and causes an IgG4/IgE ratio shift.

Aim: To investigate the blood eosinophil count, CCL5/RANTES and IL-17E/IL-25 concentrations before and after the initial phases of the rush protocol of VIT.

Material And Methods: Forty individuals (14 males, 26 females) of mean age 41.03 ±12.43 years were included in the study. The peripheral eosinophils and the concentration of serum interleukin IL-17E/IL-25 and RANTES were determined before and after the initial phase of VIT.

Results: Paired sample t-test revealed that all patients after VIT had significantly higher eosinophil levels compared to the baseline (mean: 0.42 vs. 0.64, p < 0.05). Moreover, in subjects treated with bee venom, RANTES levels proved to rise significantly (51 × 103 vs. 62 × 103, < 0.05) while IL-17E/IL-25 dropped with near-marginal significance (916 vs. 650, = 0.069).

Conclusions: Our immunological study on the early phase of venom immunotherapy suggested that eosinophils, cytokines such as CCL5/RANTES and IL-17E/IL-25 contribute to the immunological response.

Citing Articles

Time-dependent cytokines changes in ultra-rush wasp venom immunotherapy.

Urbanska W, Szymanski L, Ciepelak M, Cios A, Stankiewicz W, Klimaszewska E Sci Rep. 2023; 13(1):10560.

PMID: 37386045 PMC: 10310823. DOI: 10.1038/s41598-023-37593-0.

Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective.

Shi P, Xie S, Yang J, Zhang Y, Han S, Su S Front Pharmacol. 2022; 13:1001553.

PMID: 36238572 PMC: 9553197. DOI: 10.3389/fphar.2022.1001553.

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