Primary Aldosteronism by Carcinoma of the Adrenal Cortex

Overview

Journal Klin Wochenschr

Specialty General Medicine

Date 1987 May 4

PMID 3298831

Citations 1

Authors

W Tenschert

R Maurer

H Vetter

W Vetter

Affiliations

Soon will be listed here.

Abstract

A 58-year-old white woman with hypertension and severe hypokalemia was found to have a carcinoma of the left adrenal gland. Plasma renin activity was constantly under the normal limit, while plasma aldosterone levels were pathologically elevated. Plasma cortisol (8:00 a.m.) and excretion rates of urinary free cortisol were within the normal range. After an adrenalectomy, relapsing excessive aldosterone secretion was successfully treated with opDDD (Lysodrene). Ten months after the diagnosis was established, the patient died from a bleeding liver metastasis.

Citing Articles

[Modern pharmacological aspects of hyperaldosteronism therapy].

Quinkler M, Reincke M Internist (Berl). 2006; 47(9):953-9.

PMID: 16823578 DOI: 10.1007/s00108-006-1681-0.

References

Haber E, Koerner T, PAGE L, KLIMAN B, Purnode A . Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. J Clin Endocrinol Metab. 1969; 29(10):1349-55. DOI: 10.1210/jcem-29-10-1349. View

Brooks R, McSWINEY R, Prunty F, WOOD F . Potassium deficiency of renal and adrenal origin. Am J Med. 1957; 23(3):391-407. DOI: 10.1016/0002-9343(57)90319-4. View

FILIPECKI S, Feltynowski T, Poplawska W, Lapinska K, KRUS S, WOCIAL B . Carcinoma of the adrenal cortex with hyperaldosteronism. J Clin Endocrinol Metab. 1972; 35(2):225-9. DOI: 10.1210/jcem-35-2-225. View

Vetter W, Vetter H, Siegenthaler W . Radioimmunoassay for aldosterone without chromatography. Acta Endocrinol (Copenh). 1973; 74(3):548-57. DOI: 10.1530/acta.0.0740548. View

CONN J . Aldosteronism in man. Some clinical and climatological aspects. II. JAMA. 1963; 183:871-8. View

Tenschert W, Vetter H, Siebenschein R, Siegenthaler W, Vetter W . [Special diagnosis in Cushing's syndrome]. Schweiz Med Wochenschr. 1981; 111(3):70-3. View

Ferriss J, Brown J, Fraser R, Haywood E, Davies D, Kay A . Results of adrenal surgery in patients with hypertension, aldosterone excess, and low plasma renin concentration. Br Med J. 1975; 1(5950):135-8. PMC: 1671982. DOI: 10.1136/bmj.1.5950.135. View

CONN J . Presidential address. I. Painting background. II. Primary aldosteronism, a new clinical syndrome. J Lab Clin Med. 1955; 45(1):3-17. View

Vetter W, Vetter H, Beckerhoff R, Wittassek F, Pouliadis G, Furrer J . [Endocrine hypertension in primary aldosteronism and in Cushing's syndrome]. Schweiz Med Wochenschr. 1976; 106(50):1773-7. View

10.

Vetter W, Vetter H, Siegenthaler W . Radioimmunoassay for aldosterone without chromatography. 2. Determination of plasma aldosterone. Acta Endocrinol (Copenh). 1973; 74(3):558-67. DOI: 10.1530/acta.0.0740558. View

11.

FOYE Jr L, FEICHTMEIR T . Adrenal cortical carcinoma producing solely mineralocorticoid effect. Am J Med. 1955; 19(6):966-75. DOI: 10.1016/0002-9343(55)90163-7. View

12.

LUBITZ J, Freeman L, Okun R . Mitotane use in inoperable adrenal cortical carcinoma. JAMA. 1973; 223(10):1109-12. View

13.

Thorn G, Lauler D . Clinical therapeutics of adrenal disorders. Am J Med. 1972; 53(5):673-84. DOI: 10.1016/0002-9343(72)90162-3. View

14.

Peterson R, WYNGAARDEN J, Guerra S, Brodie B, Bunim J . The physiological disposition and metabolic fate of hydrocortisone in man. J Clin Invest. 1955; 34(12):1779-94. PMC: 438761. DOI: 10.1172/JCI103233. View

15.

Kondo K, Saruta T, Saito I, Yoshida R, Maruyama H, Matsuki S . Benign desoxycorticosterone-producing adrenal tumor. JAMA. 1976; 236(9):1042-4. View

16.

Spaulding W, Oille W, Gornall A . Mineralocorticoid-like disturbance associated with adrenal metastases from a bronchogenic carcinoma. Ann Intern Med. 1955; 42(2):444-51. DOI: 10.7326/0003-4819-42-2-444. View

17.

Murphy B, ENGELBERG W, Pattee C . Simple method for the determination of plasma corticoids. J Clin Endocrinol Metab. 1963; 23:293-300. DOI: 10.1210/jcem-23-3-293. View

18.

Zimmermann B, MORAN Jr W, Rosenberg J, Kennedy B, Frey R . Physiologic and surgical problems in the management of primary aldosteronism. Ann Surg. 1959; 150:653-65. PMC: 1613483. DOI: 10.1097/00000658-195910000-00010. View